USA flag logo/image

An Official Website of the United States Government

Immortalized Pig Hepatocytes: A Drug Discovery Model

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
65428
Program Year/Program:
2003 / SBIR
Agency Tracking Number:
CA096458
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
MULTICELL TECHNOLOGIES, INC.
MULTICELL TECHNOLOGIES, INC. 701 GEORGE WASHIGNTON HIGHWAY LINCOLN, RI 02865
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2003
Title: Immortalized Pig Hepatocytes: A Drug Discovery Model
Agency: HHS
Contract: 1R43CA096458-01
Award Amount: $139,314.00
 

Abstract:

DESCRIPTION (provided by applicant): Drug-drug interactions can occur in a multiple drug regimen, where one drug interferes with the metabolism of another, leading to dangerous, unpredicted, and potentially fatal concentrations of medication. Unfortunately, a significant number of such drug interactions are first recognized during clinical trials. This nonrecognition of drug metabolic interactions is due in part to interspecies differences between rodents and man. A recent FDA report estimated that up to 20 percent of toxicity and potential drug interactions are misidentified in rat assays because of interspecies differences. Most drugs are metabolized by the hepatic cytochrome P450 enzymes, and a non-primate species most reflective of human CYP regulation is the pig. MultiCell Associates recently developed an immortalized porcine hepatocyte cell line designated HepLiu. The purpose of this Phase I project is to determine if HepLiu and its MSX resistant progeny, HL-MSX, can be employed as a screening bioassay to reproducibly detect inducers and inhibitors of human CYPs. This will be accomplished by assaying 24 compounds, whose effects on CYP3A4 and 1A activity have been well documented in humans. A positive correlation will provide the scientific basis for the long term goal of this project: to develop a predictive and economical assay based on the HepLiu porcine hepatocyte cell line, for screening the CYP induction and inhibition potential of new chemical entities in drug discovery.

Principal Investigator:

Ronald A. Faris
4017387560
FARIS@MULTICLTECHNOLOGIES.COM

Business Contact:


4017387560
Small Business Information at Submission:

MULTICELL TECHNOLOGIES, INC.
MULTICELL TECHNOLOGIES, INC. 55 ACCESS RD, STE 700 WARWICK, RI 02886

EIN/Tax ID: 050483322
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No