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ZEAMATIN: A POSSIBLE HUMAN THERAPEUTIC ANTIFUNGAL AGENT

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
13639
Program Year/Program:
1990 / SBIR
Agency Tracking Number:
13639
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
MycoTox, Inc.
4200 East Ninth Ave., B-111 Denver, CO 00000 0802
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1990
Title: ZEAMATIN: A POSSIBLE HUMAN THERAPEUTIC ANTIFUNGAL AGENT
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

A 22-KDA PROTEIN THAT HAS POTENT ACTIVITY AGAINST A NUMBER OF CLINICALLY IMPORTANT HUMAN PATHOGENS HAS BEEN ISOLATED FROM MAIZE SEEDS. IN ADDITION, THIS PROTEIN, NAMED ZEAMATIN, HAS THE UNIQUE ABILITY TO SYNERGIZE WITH KNOWN ANTIFUNGAL DRUGS, DECREASING THE DOSE REQUIRED FOR FUNGAL CELL KILLING WHILE INCREASING THE SPECTRUM OF ACTIVITY. AS A PRELUDE TO IN VIVO TESTING, IT IS PLANNED TO DETERMINE THE TOXICITY OF ZEAMATIN AND ZEAMATIN-ANTIFUNGAL DRUG COMBINATIONS ON MAMMALIAN SKIN, CERVIX, AND KIDNEY TISSUE-CULTURE CELLS. THE EFFICACY OF ZEAMATIN AND ZEAMATIN-DRUG COMBINATIONS IN KILLING FUNGI IN TISSUE CULTURE WILL ALSO BE DETERMINED. FINALLY, THE RESEARCH WILL DETERMINE IF PEPTIDE FRAGMENTS OF ZEAMATIN HAVE ANTIFUNGAL ACTIVITY.

Principal Investigator:

Claude P Selitrennikoff
3032708647

Business Contact:

Small Business Information at Submission:

Mycotox Inc
4200 E 9th Ave #b-111 Denver, CO 80262

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No