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A LITERATURE REVIEW OF FUNGALLY DERIVED ANTITUMOR AGENTS REVEALS THAT THE FUNGI…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
4761
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
4761
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Mycosearch Inc
311 West Rosemary Road Po Box 941 Chapel Hill, NC 27514
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1986
Title: A LITERATURE REVIEW OF FUNGALLY DERIVED ANTITUMOR AGENTS REVEALS THAT THE FUNGI CONSTITUTE A GROUP OF EASILY COLLECTED SPECIES INDIGENOUS TO WESTERN EUROPE, THE EASTERN UNITED STATES, AND JAPAN.
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

A LITERATURE REVIEW OF FUNGALLY DERIVED ANTITUMOR AGENTS REVEALS THAT THE FUNGI CONSTITUTE A GROUP OF EASILY COLLECTED SPECIES INDIGENOUS TO WESTERN EUROPE, THE EASTERN UNITED STATES, AND JAPAN. THEIR AVAILABILITY MAY HAVE BEEN THE DECISIVE FACTOR IN THESE DRUG DISCOVERIES. SIGNIFICANTLY, THEIR HABITAT RANGES ARE BROAD AND SUGGEST THAT OTHER SAPROPHYTIC AND PARASITIC FUNGI, WORLDWIDE, MAY HAVE DEVELOPED DISTINCTIVE ANTITUMOR AGENTS. MYCOSEARCH PROPOSES TO SCREEN REPRESENTATIVE ISOLATES OF OVER 100 SELECTED TROPICAL AND TEMPERATE FOREST TAXA. FERMENTATION BROTHS, MYCELIAL EXTRACTS, AND AGAR PLATE CULTURES WOULD BE SCREENED AGAINST AN ADRIAMYCIN-RESISTANT TUMOR CELL CULTURE IN VITRO, USING A RAPID ASSAY. PARALLEL ANTIFUNGAL SCREENS WOULD BE PERFORMED. ALL POSITIVE CULTURES WOULD BE AVAILABLE TO NCI FOR FURTHER SCREENING AGAINST HUMAN TUMOR LINES. RESULTS MAY SUGGEST WHETHER ADDITIONAL SCREENING OF NOVEL FUNGI IS WARRANTED. FUTURE PHASE II RESEARCH WOULD INVOLVE FURTHER PRIMARY SCREENING AND PURIFICATION OF THE ANTITUMOR AGENTS FROM FUNGI.

Principal Investigator:

Barry katz
PRINCIPAL INVESTIGATOR
9199680730

Business Contact:


9199680730
Small Business Information at Submission:

Mycosearch Inc
311 West Rosemary Road Po Box 941 Chapel Hill, NC 27514

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No