USA flag logo/image

An Official Website of the United States Government

Anti-PSA single chain antibody-quantum dot conjugates

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
70700
Program Year/Program:
2004 / SBIR
Agency Tracking Number:
CA108405
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
NANOMATERIALS AND NANOFABRICATION LABORATORIES
P.O. Box 2168 Fayetteville, AR 72702 2168
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2004
Title: Anti-PSA single chain antibody-quantum dot conjugates
Agency: HHS
Contract: 1R43CA108405-01
Award Amount: $100,000.00
 

Abstract:

DESCRIPTION (provided by applicant): This SBIR proposal intends to prepare luminescent anti-PSA (prostate specific antigen) single chain antibody fragment (scFv) -- Quantum Dot (QD) conjugates that can be used for PSA immunoassays. This project will be built on our recent success in preparing luminescent, monodisperse, super stable, water-soluble, and bio-compatible dendron-boxed semiconductor nanocrystals, as well as on this Pl's earlier works in the cloning, expression and structural characterization of an anti-PSA single chain antibody fragment-scFvB80. The success of this proposal could provide a new path of making antibody-QD conjugates. In comparison with current antibody-adaptor protein-QDs conjugates, this proposed scFvB80-QDs would be directly coupled and could have the advantages of small size, simple structure, easy preparation, low production costs, and ready modification via genetic engineering. The proposed anti-PSA scFvB80-QD conjugate could have the potential for improving the PSA immunoassay.

Principal Investigator:

Yunjun Wang
4797993368
YJWANT@NN-LABS.COM

Business Contact:


4795752723
Small Business Information at Submission:

NANOMATERIALS AND NANOFABRICATION LABS
P.O. BOX 2168 FAYETTEVILLE, AR 72702

EIN/Tax ID: 731624630
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No