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Company Information:

Company Name:
NANOPROBES, INC.
Address:
95 HORSEBLOCK RD
YAPHANK, NY 11980-
Phone:
N/A
URL:
N/A
EIN:
111303845
DUNS:
784163446
Number of Employees:
N/A
Woman-Owned?:
No
Minority-Owned?:
No
HUBZone-Owned?:
No

Commercialization:

Has been acquired/merged with?:
N/A
Has had Spin-off?:
N/A
Has Had IPO?:
N/A
Year of IPO:
N/A
Has Patents?:
N/A
Number of Patents:
N/A
Total Sales to Date $:
$ 0.00
Total Investment to Date $
$ 0.00
POC Title:
N/A
POC Name:
N/A
POC Phone:
N/A
POC Email:
N/A
Narrative:
N/A

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $5,104,234.00 34
SBIR Phase II $6,614,879.00 9
STTR Phase I $128,363.00 2
STTR Phase II $878,519.00 1

Award List:

DEVELOPMENT OF AN ULTRASENSITIVE DETECTION SYSTEM FOR DNA SEQUENCING

Award Year / Program / Phase:
1991 / SBIR / Phase I
Award Amount:
$49,867.00
Agency:
DOE
Principal Investigator:
Dr Frederic R Furuya , Principal Investigator
Abstract:
A new gold particle has been developed that is water soluble, can be reacted with nucleic acids in a specific way, and is highly sensitive to silver developer. this system has experimentally demonstrated potential to detect 10(-20) mol of target. in phase i, both the coupling of thegold particle to… More

AMPLIFICATION OF SILVER-GOLD IMMUNO- AND DNA PROBES

Award Year / Program / Phase:
1991 / SBIR / Phase I
Award Amount:
$49,838.00
Agency:
HHS
Principal Investigator:
Powell, Richard D , Principal Investigator
Abstract:
New methodologies will be used for the detection and quantitization of very small amounts of proteins and dna sequences. a new gold particle will be used to label target biomolecules, then stained with metallic silver by exposure to aqueous silver (i) ions and a reducing agent. the silver will then… More

Gold-Coupled Nucleotides for Ultrasensitive Probes

Award Year / Program / Phase:
1993 / SBIR / Phase I
Award Amount:
$50,000.00
Agency:
HHS
Principal Investigator:
Richard D. Powell
Abstract:
New nucleotide reagents are proposed that have covalently attached 0.8 or 1.4 nm gold clusters. These will then be used to develop extremely sensitive and high resolution hybridization probes. Several synthetic pathways will be explored to produce gold labelled uridine and adenine nucleotide… More

Large Metal Cluster and Cluster-Polymer Immunoprobes

Award Year / Program / Phase:
1993 / SBIR / Phase I
Award Amount:
$49,992.00
Agency:
HHS
Principal Investigator:
Richard D. Powell
Abstract:
N/a

Caged Metal Cluster and Colloid Immunoprobes

Award Year / Program / Phase:
1993 / SBIR / Phase I
Award Amount:
$49,997.00
Agency:
HHS
Principal Investigator:
Richard D. Powell
Abstract:
N/a

MOLECULAR CYTOSKELETAL MICROSCOPY PROBES AND BIOLOGICAL WIRES

Award Year / Program / Phase:
1994 / SBIR / Phase I
Award Amount:
$64,993.00
Agency:
NSF
Principal Investigator:
Richard D Powell
Abstract:
Novel probes are introduced for the study of cytoskeletal structures and processes by electron microscopy. these comprise large cluster complexes of gold, plantinum, and palladium 0.8 nm-2.4 nm in diameter covalently linked to phalloidin, cytochalasin b, colchicine, and taxol via a single reactive… More

Large Metal Cluster and Cluster-Polymer Immunoprobes

Award Year / Program / Phase:
1995 / SBIR / Phase II
Award Amount:
$700,000.00
Agency:
HHS
Principal Investigator:
Richard D. Powell
Abstract:
New, molecular heavy metal cluster immunoprobes will be prepared with platinum and palladium clusters 1.8 and 2.4 nm in diameter covalently conjugated to antibodies to give immunoelectron microscopy probes. Multiple gold cluster complexes will also be combined in a single larger label, up to 5 nm in… More

Gold and Combined Fluorescent/Gold Labels for Solid-Phase DNA Synthesis

Award Year / Program / Phase:
1995 / SBIR / Phase I
Award Amount:
$64,995.00
Agency:
NSF
Principal Investigator:
Richard Powell
Abstract:
N/a

Caged Metal Cluster and Colloid Immunoprobes

Award Year / Program / Phase:
1996 / SBIR / Phase II
Award Amount:
$695,098.00
Agency:
HHS
Principal Investigator:
Richard D. Powell
Abstract:
New classes of immunolabels will be produced comprising large metal particles encapsulated within coordination shells of stabilizing ligands, the naturally occurring hollow protein apoferritin, or new synthetic inclusion molecules. The new probes will combine the high electron density, ease of… More

NICKEL CHELATING POLYHISTIDINE SPECIFIC MOLECULAR PROBE

Award Year / Program / Phase:
1996 / SBIR / Phase I
Award Amount:
$96,904.00
Agency:
HHS
Principal Investigator:
Abstract:
N/a

HEAVY ATOM CLUSTERS FOR MEMBRANE PROTEIN DERIVATIZATION

Award Year / Program / Phase:
1997 / SBIR / Phase I
Award Amount:
$96,385.00
Agency:
HHS
Principal Investigator:
Powell, richard d
Abstract:
N/a

SIGNAL AMPLIFICATION BY CATALYTIC NANOGOLD DEPOSITION

Award Year / Program / Phase:
1998 / SBIR / Phase I
Award Amount:
$100,000.00
Agency:
HHS
Principal Investigator:
Powell, Richard D
Abstract:
N/a

Fluorescent and Large Metal Cluster Combination Probes

Award Year / Program / Phase:
1998 / SBIR / Phase II
Award Amount:
$749,985.00
Agency:
HHS
Principal Investigator:
Powell, richard d
Abstract:
N/a

Autometallographic Fabrication of Copper Interconnects

Award Year / Program / Phase:
1999 / SBIR / Phase I
Award Amount:
$99,975.00
Agency:
NSF
Principal Investigator:
Richard Powell
Abstract:
N/a

LUMINESCENT LANTHANIDE CHELATES LABELS FOR IMMUNOASSAYS

Award Year / Program / Phase:
1999 / SBIR / Phase I
Award Amount:
$99,989.00
Agency:
HHS
Principal Investigator:
Vishwas N. Joshi
Abstract:
Not Available In the manufacturing of printed wiring boards (PWB's), lithographic techniques are used to transfer the pattern from a mask onto a single large substrate. The use of masks for lithography inherently results in a number of problems: the inability to generate prototype PWB's quickly;… More

N/A

Award Year / Program / Phase:
2000 / SBIR / Phase I
Award Amount:
$138,457.00
Agency:
HHS
Principal Investigator:
Richard D. Powell
Abstract:
N/a

N/A

Award Year / Program / Phase:
2000 / STTR / Phase I
Award Amount:
$128,363.00
Agency:
HHS
Principal Investigator:
Research Institution:
Cleveland Clinic Foundation
RI Contact:
N/A
Abstract:
N/a

N/A

Award Year / Program / Phase:
2000 / SBIR / Phase I
Award Amount:
$116,118.00
Agency:
HHS
Principal Investigator:
Richard D. Powell
Abstract:
N/a

N/A

Award Year / Program / Phase:
2000 / SBIR / Phase I
Award Amount:
$173,304.00
Agency:
HHS
Principal Investigator:
James F. Hainfeld
Abstract:
N/a

Enzymatic Metallography for Biological Detection

Award Year / Program / Phase:
2001 / SBIR / Phase I
Award Amount:
$106,000.00
Agency:
HHS
Principal Investigator:
Richard D. Powell
Abstract:
A new signal amplification procedure is described in which metals, rather than organic molecules, are catalytically deposited at a labeling site by an enzyme bound to an antibody or other biologically targeted probe. Preliminary experiments suggest that the new system is highly effective for in situ… More

GOLD QUENCHED MOLECULAR BEACONS

Award Year / Program / Phase:
2002 / SBIR / Phase I
Award Amount:
$0.00
Agency:
HHS
Principal Investigator:
Abstract:
Molecular beacons are hairpin loops of DNA, conjugated to a fluorescent label at one end and a quencher at the other. Upon binding to a complementary target, the beacon opens, the fluorophore and quencher move apart, and fluorescence appears. Sensitivity is dependent upon the "signal-to-noise ratio"… More

CHROMOGENIC HER-2/NEU GENE AMPLIFICATION ASSAY

Award Year / Program / Phase:
2002 / STTR / Phase I
Award Amount:
$0.00
Agency:
HHS
Principal Investigator:
Research Institution:
CLEVELAND CLINIC FOUNDATION
RI Contact:
N/A
Abstract:
Overexpression of the Her-2/neu protein and amplification of the Her-2/neu gene are are the most widely accepted prognostic indicator of aggressive malignant behavior of invasive breast carcinoma. Accurate detection of Her-2/neu overexpression is critical in identifying patients suitable for… More

GOLD QUENCHED MOLECULAR BEACONS

Award Year / Program / Phase:
2002 / SBIR / Phase II
Award Amount:
$1,037,403.00
Agency:
HHS
Principal Investigator:
Abstract:
Molecular beacons are hairpin loops of DNA, conjugated to a fluorescent label at one end and a quencher at the other. Upon binding to a complementary target, the beacon opens, the fluorophore and quencher move apart, and fluorescence appears. Sensitivity is dependent upon the "signal-to-noise ratio"… More

IMPROVED MRI CONTRAST AGENTS

Award Year / Program / Phase:
2002 / SBIR / Phase I
Award Amount:
$185,313.00
Agency:
HHS
Principal Investigator:
Abstract:
A new class of MRI contrast agents has been discovered and synthesized by Nanoprobes. Initial MRI animal studies showed excellent definition of some types of brain tumors, which were undetectable with the commonly used agent, gadodiamide. Furthermore, initial toxicity studies showed the agents to… More

LIVE CELL CORRELATIVE IMAGING PROBES

Award Year / Program / Phase:
2002 / SBIR / Phase I
Award Amount:
$129,956.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant):Probes will be prepared, based on the 1.4 nm Nanogold cluster label, for the correlative fluorescence and electron microscopy of living cells, which may be transfected without requiring physical or chemical disruption of the cell membrane for transfection. Three… More

Reiterative Signal Amplification by Gold Deposition

Award Year / Program / Phase:
2003 / SBIR / Phase I
Award Amount:
$173,703.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant): We propose a new approach to signal amplification for ultrasensitive, high-resolution localization of targets in cells and tissues. Amplification will be conducted using reiterative cycles of discrete, highly specific chemical reactions, each of which introduces… More

Correlative Chromogenic Gene and Protein assessment

Award Year / Program / Phase:
2004 / SBIR / Phase I
Award Amount:
$175,261.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant): We propose a comprehensive HER2 status assay for gene amplification detection with concomitant protein assessment and an internal control for chromosome 17 polysomy in a single brightfleld light microscope slide staining protocol. Gene copy, protein… More

GOLD ENHANCED ANGIOGRAPHY

Award Year / Program / Phase:
2004 / SBIR / Phase I
Award Amount:
$216,720.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant): Coronary artery disease is the leading cause of death in the U.S. Tests are urgently needed that can detect and distinguish vulnerable plaque formation so that they may be treated before a catastrophic event. Angiography is a useful tool for assessment of… More

Nanoparticle Contrast Agents: MicroCT Of Colon Cancer

Award Year / Program / Phase:
2004 / SBIR / Phase I
Award Amount:
$198,496.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant): Recent advances in microCT machines have made it possible to image with a resolution of

GOLD ENHANCED ANGIOGRAPHY

Award Year / Program / Phase:
2004 / SBIR / Phase II
Award Amount:
$1,002,016.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant): Coronary artery disease is the leading cause of death in the U.S. Tests are urgently needed that can detect and distinguish vulnerable plaque formation so that they may be treated before a catastrophic event. Angiography is a useful tool for assessment of… More

Enzymatic Metallography for Ultrasensitive Biodetection

Award Year / Program / Phase:
2005 / SBIR / Phase II
Award Amount:
$751,554.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant): A novel process has been discovered in which an enzyme linked to an antibody or biological targeting agent directed to a site of interest deposits metal rapidly and highly selectively from solution. Sensitivity and resolution are both higher then with… More

Nanogold-Enhanced Head & Neck Cancer Radiotherapy

Award Year / Program / Phase:
2005 / SBIR / Phase I
Award Amount:
$189,613.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant): Head and neck cancers strike 41,000 new persons each year in the U.S. Survival is only 50% and treatments leave most patients with functional deficits and disfiguration. Improved treatments are desperately needed. In preliminary studies, we achieved high… More

Correlative Enzymatic and Gold Probes

Award Year / Program / Phase:
2005 / SBIR / Phase I
Award Amount:
$169,401.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant): A new type of immunoprobe will be developed, containing both an enzyme and a covalently linked 1.4 nm, 3 nm, 5 nm or 10 nm gold label. These will be used for correlative microscopic staining of biologically significant targets at the cell and tissue level by… More

Gold Nanoparticle Contrast Agents: MicroCT of Colon Cancer

Award Year / Program / Phase:
2006 / SBIR / Phase II
Award Amount:
$887,575.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant): This proposal seeks to develop new contrast agents for in vivo microCT x-ray imaging based on non- toxic gold nanoparticles that would provide additional useful features over current agents including: a) longer imaging times, b) higher contrast, and c) targeted,… More

Molecular Mammography of Her-2 Cancers using Gold Nanoparticles

Award Year / Program / Phase:
2006 / SBIR / Phase I
Award Amount:
$179,787.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant): Cancer imaging is important for tumor detection, determination of prognosis and treatments, image guided surgery and irradiation, as well as for monitoring responses. Molecular imaging of specific targets could identify tumor types and enable selection of… More

Infrared and X-ray Nanogold Therapy of Head and Neck Cancers

Award Year / Program / Phase:
2008 / SBIR / Phase I
Award Amount:
$199,947.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant): This proposal is based on a recent discovery that tumors can bioconvert non-absorbing small metal nanoparticles into intense infrared (IR) absorbers. In preliminary tests, non-IR absorbing 15 nm gold nanoparticles were immunotargeted to human tumors in mice… More

Improved Renal Diagnoses using Gold Nanoparticle CT Imaging

Award Year / Program / Phase:
2008 / SBIR / Phase I
Award Amount:
$199,930.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant): Over 10 million Americans suffer from chronic kidney disease and kidney cancer, resulting in 109,000 deaths a year and disability to many times that number. Better methods to study renal function and detect and accurate ly diagnose pathology are needed. Imaging… More

Nanogold-Enhanced Radiosurgery for Malignant Brain Tumors

Award Year / Program / Phase:
2008 / SBIR / Phase I
Award Amount:
$168,449.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant): This proposal builds on the unprecedented success achieved by our earlier studies in safely ablating malignant EMT-6 carcinomas in the thighs of mice by using photoactivation radiosurgery mediated by gold nanoparticles (so-called metal-enhanced radiosurgery… More

Polymeric Enzyme-Gold Probes for Ultrasensitive Protein Blotting

Award Year / Program / Phase:
2008 / SBIR / Phase I
Award Amount:
$180,349.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant): We propose to develop ultrasensitive detection reagents for protein blotting which will provide users with a means to detect as little as 0.001 to 0.0002 amol (10-21 to 2 x 10-22 mol) of a protein target in a two hour p rocedure. The high sensitivity will be… More

Molecular Mammography of Her-2 Cancers using Gold Nanoparticles

Award Year / Program / Phase:
2009 / SBIR / Phase II
Award Amount:
$0.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant): This is a Competitive Revision application under Notice Number NOT-OD-09-058, with Notice Title NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications . It is for the existing Phase II SBIR grant Molecular Mammography of Her-2… More

Serial Blockface SEM Labels for Assessing Nervous System Plasticity

Award Year / Program / Phase:
2009 / SBIR / Phase I
Award Amount:
$699,944.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant): Serial blockface scanning electron microscopy (SBFSEM) is a recently developed electron microscopy serial- reconstruction technique which automates the process of sectioning and imaging blocks of tissue by incorporating a microtome into the vacuum chamber of a… More

3 to15 Covalent Gold for High Resolution Electron Microscopy

Award Year / Program / Phase:
2009 / SBIR / Phase I
Award Amount:
$164,472.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant): Covalently linkable 3-15 nm gold reagents will be prepared stabilized with formulations that incorporate a hydrophobic chelating thiol domain for stabilizing the gold nanoparticles, and hydrophilic surface groups that p rovide a wide choice of surface properties… More

Infrared and X-ray Nanogold Therapy of Head and Neck Cancers

Award Year / Program / Phase:
2011 / SBIR / Phase II
Award Amount:
$791,248.00
Agency:
HHS
Principal Investigator:
James F. Hainfeld – 631-205-9490
Abstract:
DESCRIPTION (provided by applicant): This proposal is based on a recent discovery that tumors can bioconvert non-absorbing small metal nanoparticles into intense infrared (IR) absorbers. In preliminary tests, non-IR absorbing 15 nm gold nanoparticles wereimmunotargeted to human tumors in mice which… More

Novel tungsten and bismuth nanoparticle contrast agents for MicroCT.

Award Year / Program / Phase:
2012 / SBIR / Phase I
Award Amount:
$228,895.00
Agency:
HHS
Principal Investigator:
Vishwas N. Joshi – 631-205-1682
Abstract:
DESCRIPTION (provided by applicant): Recent advances in microCT machines have made it possible to image with a resolution of lt 10 m. Scans take ~6 to 20 minutes to acquire, and current iodine contrast agents due to their short half life are not generallysuitable. We recently commercialized gold… More

Biodegradable polymeric iodine contrast agents for CT angiography.

Award Year / Program / Phase:
2013 / SBIR / Phase I
Award Amount:
$237,184.00
Agency:
HHS
Principal Investigator:
Vishwas N. Joshi – 631-205-1682
Abstract:
DESCRIPTION (provided by applicant): Recent advances in micro-CT machines have made it possible to image with a resolution of lt10 m. Scans take ~6 to 20 minutes to acquire, and current iodine contrast agents due to their short half-lives are not generally suitable. We recentl commercialized… More