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GOLD ENHANCED ANGIOGRAPHY

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
70948
Program Year/Program:
2004 / SBIR
Agency Tracking Number:
HL076046
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
NANOPROBES, INC.
95 HORSEBLOCK RD YAPHANK, NY 11980-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2004
Title: GOLD ENHANCED ANGIOGRAPHY
Agency: HHS
Contract: 1R44HL076046-01
Award Amount: $216,720.00
 

Abstract:

DESCRIPTION (provided by applicant): Coronary artery disease is the leading cause of death in the U.S. Tests are urgently needed that can detect and distinguish vulnerable plaque formation so that they may be treated before a catastrophic event. Angiography is a useful tool for assessment of stenoses, and contrast agents that could be administered non-invasively and visualize composition as well as morphology should be developed. Nanoprobes, Inc. has combined nanotechnology with this medical application and developed the use of tiny nanoparticles as x-ray contrast agents. These have a number of advantages over the current iodine compounds: they provide longer imaging times, have lower osmolality to reduce side effects, are higher in atomic number so that the dose of x-rays can be reduced, and can be concentrated more than iodine agents. Preliminary imaging in mice revealed 0.2 mm vessels and visualization of many internal organs with great clarity not possible with the current contrast agents. Phase I will concentrate on and comparing the performance of the new agents with the iodine agents, quantifying their properties, and measuring acute and subacute toxicity. A further objective of this work to be explored in Phase II is the development of targeted contrast agents that would be able to discriminate high-risk atherosclerotic plaques.

Principal Investigator:

James F. Hainfeld
6312059490
HAINFELD@NANOPROBES.COM

Business Contact:

James Hainfeld
6312059490
HAINFELD@NANOPROBES.COM
Small Business Information at Submission:

NANOPROBES, INC.
NANOPROBES, INC. 95 HORSEBLOCK RD YAPHANK, NY 11980

EIN/Tax ID: 113038451
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No