Photo-curable Biodegradable-based Tissue Solders containing a Photochromic Endpoint Indicator
Agency / Branch:
DOD / OSD
"The purpose of the proposed Army Phase II program is to develop and commercialize novel tissue solders based on a biodegradable copolymer system that contains a controlled degree of acrylate-terminated photoactive branch sites. This will result in aprocess that, with the addition of a biocompatible and non-toxic photosensitizer /electron donor initiating system, will rapidly cure from a viscous liquid to a tough ductile polymer in a matter of milliseconds. This reaction occurs with a minimal heat ofpolymerization in an oxygen-containing aqueous environment at physiological pH. The free-radical cure reaction is easily triggered by applying a filtered and focused light beam of known power via optical fiber from a source with a broad wavelength range tothe synthetic solder (polymer/initiator) formulation. During Phase II, we would work with a biomedical institute partner and investor to further develop the tissue solder system by maximizing adhesion, minimizing cure/illumination time, and maximize watertransfer in the resulting system. Additionally, we plan to investigate an alternative biocompatible photosensitive endpoint indicator that responds (via cure) to visible wavelength stimulation and continue development of a compact light emittingdiode-based photon delivery system that can be easily integrated into existing soldier-based light sources."
Small Business Information at Submission:
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