USA flag logo/image

An Official Website of the United States Government

IDENTIFICATION OF NOVEL TOPOISOMERASE INHIBITORS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
11158
Program Year/Program:
1989 / SBIR
Agency Tracking Number:
11158
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Natra Cure
175 5th Ave #1101 New York, NY 10010
View profile »
Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1989
Title: IDENTIFICATION OF NOVEL TOPOISOMERASE INHIBITORS
Agency: HHS
Contract: N/A
Award Amount: $48,675.00
 

Abstract:

PLANT EXTRACTS AND TRADITIONAL MEDICINES HAVE LONG BEEN THOUGHT TO CONTAIN BIOACTIVE MOLECULES CAPABLE OF ELICITING A THERAPEUTIC RESPONSE. HOWEVER, THE POTENTIAL UTILITY OR MODE OF ACTION OF THESE NATURAL PRODUCTS HAS NOT BEEN EFFECTIVELY STUDIED IN WESTERN SCIENTIFIC RESEARCH. RECENT ADVANCES IN THE MOLECULAR UNDERSTANDING OF DRUG ACTION WILL BE EMPLOYED IN PHASE I IN AN EFFORT TO IDENTIFY AND FURTHER EVALUATE THE BIOACTIVITY OF NATURAL PRODUCTS. PLANT EXTRACTS AND TRADITIONAL MEDICINES WILL BE ANALYZED IN A HIGH-THROUGHPUT BIOCHEMICAL ASSAY FOR THEIR ABILITY TO INHIBIT TOPOISOMERASE ACTIVITY IN TRANSFORMED CELL LINES. BECAUSE TOPOISOMERASES HAVE BEEN IDENTIFIED AS THE PRIMARY TARGET OF SOME OF THE MOST POPULAR ANTINEOPLASTIC DRUGS CURRENTLY IN USE, THIS ASSAY WOULD IDENTIFY NATURAL PRODUCTSTHAT WOULD ULTIMATELY BE DEVELOPED INTO NOVEL ANTICANCER AGENTS. THE ABILITY OF LEAD COMPOUNDS TO INHIBIT TOPOISOMERASE ACTIVITY IN VITRO USING PURIFIED TOPOISOMERASE I AND II, AS WELL AS THEIR ABILITY TO INHIBIT THE GROWTH IN TRANSFORMED CELLS IN VITRO, WILL ALSO BE EVALUATED. PROMISING LEAD COMPOUNDS WOULD BE FURTHER PURIFIED AND DEVELOPED AS ANTICANCER AGENTS IN PHASE II.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Natra Cure
175 5th Ave #1101 New York, NY 10010

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No