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Promoter Rescue Vectors

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
66541
Program Year/Program:
2003 / SBIR
Agency Tracking Number:
GM069134
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
NATURE TECHNOLOGY CORPORATION
4701 INNOVATION DRIVE LINCOLN, NE 68521-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2003
Title: Promoter Rescue Vectors
Agency: HHS
Contract: 1R43GM069134-01
Award Amount: $142,017.00
 

Abstract:

DESCRIPTION (provided by applicant): Mouse VL30 (retrotransposon) long terminal repeats (LTRs) are a potential source of tissue-specific transcriptional promoters that can be used to deliver and express therapeutic genes in humans. Such vectors are badly needed, because the current retroviral vectors appear to be effective only in hematopoietic cells in vivo. In phase I, a retro-vector system will be developed for rescuing LTR promoters, and for delivery and expression of foreign genes in a tissue-specific manner. Murine skeletal muscle, liver and dendritic cells will be used as the source for potentially tissue-specific promoters, which will be tested for reporter gene expression (green fluorescent protein) in homologous and heterologous human cells. A successful promoter-trapping vector will help to overcome the limited repertoire of cells that can presently be treated with retroviral vectors. Phase II work will use high-throughput combinatorial methods to generate highly specialized promoters for gene therapy.

Principal Investigator:

Clague P. Hodgson
4024726530
HODGSON@NATX.COM

Business Contact:

Maria Meyers
4024726530
MARIA@NATX.COM
Small Business Information at Submission:

NATURE TECHNOLOGY CORPORATION
NATURE TECHNOLOGY CORPORATION 4701 INNOVATION DR LINCOLN, NE 68521

EIN/Tax ID: 341612109
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No