A quantitative high-throughput gene chip assay, ArrayPlateTM, based on nuclease protection has been developed for drug discovery. We will use this technology to develop an assay that can measure in a single well of a 96-well microplate, the differentiation of stem cells to osteoblasts or myoblasts… More

A quantitative high-throughput gene chip assay, ArrayPlateTM, based on nuclease protection has been developed for drug discovery. We will use this technology to develop two novel assays designed to screen for compounds that affect the expression of transcription factors and regulated… More

This Small Business Innovation Research (SBIR) Phase II project aims to develop a plate washer capable of washing very high-density plates, such as 1536 well plates, for ELISA and high-throughput screening assays. Currently, there are automated plate washers for 96 and 384 well plates, but there … More

DESCRIPTION (provided by applicant): This Phase II grant proposes to screen for 100,000 compounds that stimulate differentiation of adult human mesenchymal stem cells using a multiple mRNA assay, in 96-well plates. The assay quantifies induction of genes that signal differentiation to osteoblasts,… More

This Small Business Innovation Research (SBIR) Phase II project aims to develop a plate washer capable of washing very high-density plates, such as 1536 well plates, for ELISA and high-throughput screening assays. Currently, there are automated plate washers for 96 and 384 well plates, but there … More

DESCRIPTION (provided by applicant): In Phase I, newly available natural product extracts will be tested to find compounds that specifically target genes that are critical for the androgen receptor pathway of growth stimulation in recurrent prostate cancer s. This is important because the androgen… More

DESCRIPTION (provided by applicant): The overall objective of the work proposed in this grant is to find novel drugs that help to prevent metastasis. In Phase I, newly available natural product extracts will be tested to find compounds that specifically ta rget genes that are critical for the… More

This Small Business Innovation Research (SBIR) Phase I project is designed to discover compounds from a unique Natural Products Library that block the altered patterns of gene expression seen in pancreatic cancer. The extract and fraction library to be screened is from Dr. Gunatilaka at the… More

This Small Business Innovation Research (SBIR) Phase I project will help develop the first effective therapy for late stage hormone refractory Prostate Cancer (PCa). These late stage tumors rely on the Androgen Receptor (AR) pathway, but do not require androgen. Genetic changes allow tumors to use… More

This Small Business Innovation Research (SBIR) Phase II project is to address the high lethality of pancreatic cancer. Screening has begun with Phase IB funding, of natural products from the Sonoran Desert that have produced other promising drug candidates, testing effects on human pancreatic cancer… More