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RADIOIODINATED CONJUGATES FOR THERAPY AND DIAGNOSIS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
3089
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
3089
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
NEORX CORPORATION
410 W HARRISON ST SEATTLE, WA 98119
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1986
Title: RADIOIODINATED CONJUGATES FOR THERAPY AND DIAGNOSIS
Agency: HHS
Contract: N/A
Award Amount: $500,000.00
 

Abstract:

THE PURPOSE OF THIS CONTRACT PROPOSAL IS TO DEVELOP NEW RADIOIODINE-LABELED CONJUGATES FOR MONOCLONAL ANTIBODIES THAT CAN BE USED IN DIAGNOSIS AND THERAPY OF CANCER. THE GOAL OF OUR PROPOSED RESEARCH IS TO INVESTIGATE A NOVEL METHOD OF INTRODUCING HIGH SPECIFIC ACTIVITY RADIOIODINE INTO SOME SMALL MOLECULES WHICH CAN BE CONJUGATED TO MONOCLONAL ANTIBODIES. OUR APPROACH TO DEVELOP NEW CONJUGATES IS PATTERNED AFTER THE COMMERCIALLY AVAILABLE BOLTON-HUNTER AND WOOD'S REAGENTS, WHERE THE RADIOIODINATIONS ARE CARRIED OUT IN A SEPARATE REACTION VESSEL SO THAT THE ANTIBODY IS NOT EXPOSED TO THE HARSH OXIDIZING CONDITIONS OF THE RADIOIODINATION. ONE IMPORTANT DIFFERENCE BETWEEN THE MENTIONED REAGENTS AND THE REAGENTS THAT WE WILL BE RADIOIODINATING IN OUR PROPOSED STUDIES IS THAT THE RADIOIODINE WILL BE ATTACHED TO A NONACTIVATED AROMATIC RING. THIS SHOULD IMPART AN INCREASED STABILITY AGAINST CHEMICAL AND ENZY-MATIC DEGRADATION. THIS PHASE I STUDY WILL INCLUDE THE SYNTHESIS OF TARGETED COMPOUNDS, STUDIES OF RADIOIODINATION REACTION CONDITIONS, AND STUDIES LEADING TO EVENTUAL RADIOPHARMACEUTICAL ""KIT'' FORMULATIONS.

Principal Investigator:

D. Scott Wilbur
Principal Investigator
2062817001

Business Contact:

Small Business Information at Submission:

Neorx Corp.
410 West Harrison Seattle, WA 98119

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No