USA flag logo/image

An Official Website of the United States Government

A Novel High-Intensity Area X-ray Source

Award Information

Department of Health and Human Services
Award ID:
Program Year/Program:
2004 / STTR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
Nesch, LLC
1105 W 163rd Ave Crown Point, IN -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 2004
Title: A Novel High-Intensity Area X-ray Source
Agency: HHS
Contract: 1R41RR020836-01
Award Amount: $100,000.00


DESCRIPTION (provided by applicant): Diffraction enhanced imaging (DE I) is a novel approach to X-ray imaging, which can revolutionize X-ray medical imaging, because of its greater contrast at lower X-ray doses than conventional radiography. DEI relies on measuring tiny angular deflections of a collimated X -ray beam as it passes through the object (patient) in acquiring the images. The capability of DEI detecting low-density features in low-density matrices will make it especially useful in medical diagnoses and research. An essential prerequisite for optimizing DEI and using it with highly reproducible and predictable precision in a routine application such as medical applications is to have sufficiently intense X-ray source. Such are only available at synchrotron sources or possibly with very high-power rotating anode X-ray sources, which are expensive to purchase and complex to operate. The potential impact of this technology in medical imaging research, and subsequently in clinical use, will far exceed the current or projected capacity of available synchrotron beam lines. The use of DEI in clinical or laboratory settings will create an unprecedented market for specialty high-intensity X-ray sources. Unlike most X-ray imaging methods, DEI does not require a point source of radiation. Furthermore, DEI can fully use a line source due to its use of diffracting crystal optics, while having extremely high resolution in one direction defined by the projected source line width, and in the other defined by the detector resolution. Therefore, production of a high-intensity line X-ray source is of primary importance for widespread DEI application. In general, our goal is to enable the implementation of DEI in different areas such as clinical settings outside the synchrotron facilities. Specifically we propose to: 1) Design, bulled, and test a novel, stationary anode, area X-ray source (50 mm x 12 mm electron impact area) for much higher intensity X-ray emission than is currently feasible from a sealed X-ray source by employing dispenser emitter cathodes (not known to have been used in similar applications before), and 2) Experimentally characterize the uniformity, stability and reliability of the source performance over extended periods of time. Based on the knowledge and the experience we have, we are confident that the approach we will take is realistic and feasible. At the completion of the proposed Phase I project, we anticipate the following results: 1. A working alpha prototype (system). 2. A performance characterization of the system.

Principal Investigator:

Ivan Nesch

Business Contact:

Small Business Information at Submission:

NESCH, LLC. 1105 W 163RD AVE, STE 303 CROWN POINT, IN 46307

EIN/Tax ID: 352150421
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
Chicago, IL 60616
RI Type: Nonprofit college or university