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RETROVIRUSES ARE A RELATIVELY NEWLY RECOGNIZED GROUP OF RNA VIRUSES.

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
4762
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
4762
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Neushul Mariculture Inc.
475 Kellogg Way Goleta, CA 93117
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1986
Title: RETROVIRUSES ARE A RELATIVELY NEWLY RECOGNIZED GROUP OF RNA VIRUSES.
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

RETROVIRUSES ARE A RELATIVELY NEWLY RECOGNIZED GROUP OF RNA VIRUSES. MANY ARE ASSOCIATED WITH MALIGNANCIES IN MAMMALS, AND THE VIRUS THAT HAS BEEN IDENTIFIED IN CASES OF ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS) IS A RETROVIRUS. DUE TO THE SEVERITY OF AIDS, IT HAS BEEN PLACED AT THE TOP OF THE NATIONS'S HEALTH PRIORITIES. ANTIVIRAL AGENTS ARE BEING SOUGHT TO TREAT CASES OF AIDS AND OTHER RETROVIRAL INFECTIONS. IN THE COURSE OF TESTING MARINE ALGAE FOR ANTIVIRAL ACTIVITY, IT WAS FOUND THAT ONE PARTICULAR ALGA SHOWED SIGNIFICANT IN VITRO ACTIVITY AGAINST THE LEUKEMIA VIRUS, A RETROVIRUS. THE GOAL OF THE PROPOSED RESEARCH IS TO DETERMINE IF THIS IN VITRO ACTIVITY WILL BE USEFUL TO TREAT RETROVIRUS-ASSOCIATED DISEASE IN HUMANS. THE OBJECTIVES OF THIS PHASE I RESEARCH ARE TO ESTABLISH THE NATURE AND MAGNITUDE OF THE ANTIVIRAL ACTIVITY OF THIS ALGA BY USING SEVERAL IN VITRO ASSAYS. IN ADDITION, THE ACTIVE AGENT(S) WILL BE PURIFIED AND IDENTIFIED. THE FIRST STAGES OF THIS WORK WILL INVOLVE DETERMINING WHAT TYPE OF COMPOUND IS RESPONSIBLE FOR THIS ACTIVITY AND THEN SEPARATING IT FROMTHE CRUDE ALGAL EXTRACTS. CHARACTERIZATION OF THE AGENT(S) INVOLVED WILL ALSO PROVIDE INFORMATION USEFUL IN HYPOTHESIZING A MECHANISM OF ACTION.

Principal Investigator:

Bruce w w harger
PRINCIPAL INVESTIGATOR
8059645844

Business Contact:

Small Business Information at Submission:

Neushul Mariculture Inc
5755 Thornwood Drive Goleta, CA 93117

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No