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Company Information:

Name: NEW ENGLAND BIOLABS, INC.
Address: 240 County Road
IPSWICH, MA
Located in HUBZone: No
Woman-Owned: No
Minority-Owned: No
Phone: N/A

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $3,341,044.00 26
SBIR Phase II $7,699,164.00 11
STTR Phase I $417,203.00 3
STTR Phase II $1,329,932.00 2

Award List:

Identification of Nematode Nuclear Hormone Receptors

Award Year / Program / Phase: 1994 / SBIR / Phase I
Agency: HHS
Principal Investigator: Claude Maina
Award Amount: $74,935.00
Abstract:
Analogs of steroid hormones have been a fruitful source of a variety of drug therapies as theyeasily cross cell membranes and modulate transcriptional activity via their nuclear hormone receptors(NHR). The identification of nematode steroid hormones, and subsequently their analogs, could be… More

Novel Protein Kinase Substrates

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: HHS
Principal Investigator: Richard Roberts
Award Amount: $99,480.00
Abstract:
Protein kinases play a key role in the regulation of metabolic activities in eukaryotic cells. A laprotein kinases have been isolated and characterized, but we are still in the early stages of undersphosphorylation on the target proteins. Better tools are needed to study protein kinases and the… More

Engineering New Restriction Endonucleases

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: HHS
Principal Investigator: Ira Schildkraut
Award Amount: $77,719.00

Engineering New Restriction Endonucleases

Award Year / Program / Phase: 1996 / SBIR / Phase II
Agency: HHS
Principal Investigator: Ira Schildkraut
Award Amount: $680,165.00
Abstract:
Restriction endonucleases are of great importance to molecular DNA cloning, DNA diagnostics and genengineering. There is an ever increasing demand for a larger repertoire of recognition specificitiesendonuclease field is at point where the engineering of cleavage specificities is approachable.… More

PHOSPHO SPECIFIC ANTIBODIES--GROWTH FACTOR SIGNALING

Award Year / Program / Phase: 1996 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $99,332.00

NOVEL SCREEN FOR RESTRICTION ENDONUCLEASES

Award Year / Program / Phase: 1997 / SBIR / Phase I
Agency: HHS
Principal Investigator: Roberts, richard j
Award Amount: $100,000.00

PROTEIN PURIFICATION USING INTEIN C TERMINAL CLEAVAGE

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency: HHS
Principal Investigator: Chong, Shaorong
Award Amount: $93,902.00

N/A

Award Year / Program / Phase: 1999 / SBIR / Phase II
Agency: HHS
Principal Investigator: Roberts richard j
Award Amount: $693,122.00

DISCOVERING NEW RARE CUTTING RESTRICTION ENZYMES

Award Year / Program / Phase: 1999 / SBIR / Phase I
Agency: HHS
Principal Investigator: Elisabeth A. Raleigh
Award Amount: $94,450.00
Abstract:
Not Available A method is proposed for production of high density, refractory ceramic materials using Selective Laser Sintering (SLS). Conventional methods of solid freeform fabrication have been used to produce ceramic materials, but it is difficult to make a material that sinters to its full… More

ENGINEERING NEW NICKING ENDONUCLEASES

Award Year / Program / Phase: 1999 / SBIR / Phase I
Agency: HHS
Principal Investigator: Huimin Kong
Award Amount: $93,880.00
Abstract:
Not Available Materiel handling is critical to many enterprises, from military operations to shipboard loading. However, materiel handling is time-consuming and expensive, primarily because it requires extensive human labor. When working with hazardous environments or materials, the expense… More

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: HHS
Principal Investigator: Shaorong Chong
Award Amount: $0.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase II
Agency: HHS
Principal Investigator: Shaorong Chong
Award Amount: $304,431.00

Engineering New Nicking Endonucleases

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator: Huimin Kong
Award Amount: $0.00
Abstract:
Restriction endonucleases are essential tools in genetic engineering, cloning and DNA diagnostics. N.BstNBI is a natural occurring nicking endonuclease which only breaks one strand of double-stranded DNA, and it is the only nicking enzyme that is commercially available. The proposed research is… More

Engineering New Nicking Endonucleases

Award Year / Program / Phase: 2001 / SBIR / Phase II
Agency: HHS
Principal Investigator: Huimin Kong
Award Amount: $392,231.00
Abstract:
Restriction endonucleases are essential tools in genetic engineering, cloning and DNA diagnostics. N.BstNBI is a natural occurring nicking endonuclease which only breaks one strand of double-stranded DNA, and it is the only nicking enzyme that is commercially available. The proposed research is… More

Cloning and Engineering of Nicking enzymes

Award Year / Program / Phase: 2004 / STTR / Phase I
Agency: HHS
Research Institution: UNIVERSITY OF NEBRASKA LINCOLN
Principal Investigator: Shuangyong Xu
Award Amount: $104,000.00
RI Contact: N/A
Abstract:
DESCRIPTION (provided by applicant): This proposal is aimed towards cloning, expression and engineering of DNA nicking enzymes. Two nicking enzymes CviNY2A and CviNYSI have been found in Chlorella-like algae virus strains NY2A and NYSI with three-nucleotide recognition sequence. The cloning and… More

Kilo-base Range Isothermal DNA Amplification

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: HHS
Principal Investigator: Huimin Kong
Award Amount: $99,117.00
Abstract:
DESCRIPTION (provided by applicant): The ability to amplify and subsequent detection a target sequence with a limited length may satisfy the need for diagnosing some of the diseases. Nevertheless, much biomedical research, such as cloning genes and analysis of genetics variation, often demands… More

Development of a novel nematode/Wolbachia target

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: HHS
Principal Investigator: Clotilde K. Carlow
Award Amount: $97,515.00
Abstract:
DESCRIPTION (provided by applicant): Parasitic nematodes are responsible for a number of severe diseases in humans and animals. Approximately $600 million is spent each year in drugs to treat nematode infections in animals. These drugs are not completely effective so the discovery of new therapies… More

Engineering DNA nicking endonucleases

Award Year / Program / Phase: 2005 / STTR / Phase II
Agency: HHS
Research Institution: UNIVERSITY OF NEBRASKA
Principal Investigator: Shuangyong Xu
Award Amount: $568,340.00
RI Contact: N/A
Abstract:
DESCRIPTION (provided by applicant): In Phase I, the cviPIIM, cviPIINt, cviQXIM, cviQXINt genes were cloned and sequenced. Recombinant Nt.CviPII was expressed in E.coli and purified. Nt.CviQXI was expressed in E.coli and by an in vitro transcription/translation system. Nt.Sapl and Nb.Sapl were… More

Prevention of Recombinant Protein Aggregation in E.coli

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: HHS
Principal Investigator: Shaorong Chong
Award Amount: $98,880.00
Abstract:
DESCRIPTION (provided by applicant): The goal of the project is to use a novel approach to prevent recombinant protein misfolding and aggregation during overexpression in E. coli. The system used in this project consists of an aggregation-prone protein fused to a reporter protein (green fluorescent… More

A universal DNA endonuclease

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: HHS
Principal Investigator: Shuangyong Xu
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant): The goal of this proposal is to engineer universal restriction endonucleases with tailored cleavage specificities. The universal endonucleases will contain two functional components: 1) a specificity determinant and 2) a cleavage domain. The DNA binding… More

Development of a novel nematode/Wolbachia target

Award Year / Program / Phase: 2006 / SBIR / Phase II
Agency: HHS
Principal Investigator: Clotilde K. Carlow
Award Amount: $750,000.00
Abstract:
DESCRIPTION (provided by applicant): Parasitic nematodes are responsible for a number of severe diseases in humans, animals and plants. Approximately $600 million is spent each year on drugs to treat nematode infections in animals. These drugs are not completely effective so the discovery of new… More

A Genetic System Able to Screen for Active DNA Demethylation

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: HHS
Principal Investigator: Shuangyong Xu
Award Amount: $104,000.00
Abstract:
DESCRIPTION (provided by applicant): With the increasing interest in epigenetic modification of DNA there is a need for research reagents to help study the phenomenon. Of especial interest would be an enzyme able to demethylate DNA that might provide a direct way to measure the extent of methylation… More

Simultaneous Control of Expression of Two Genes in Mammalian Tissue Culture

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: HHS
Principal Investigator: Claude Maina
Award Amount: $132,223.00
Abstract:
DESCRIPTION (provided by applicant): The ability to control expression of a cloned gene both temporally and quantitatively is critical to the study of its function. For two interacting genes or gene products, the ability to control both the timing and leve l of expression, independently, is… More

Engineering Useful Type I restriction enzymes

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: HHS
Principal Investigator: Geoffrey G. Wilson
Award Amount: $107,000.00
Abstract:
DESCRIPTION (provided by applicant): Restriction enzymes are essential laboratory tools for analyzing and cloning DNA. Two principal kinds exist in nature that differ in the way they cleave the substrate. Type II restriction enzymes cleave DNA at fixed pos itions with respect to their recognition… More

Expression System for Isolation of Membrane Associated Protein

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $107,000.00
Abstract:
DESCRIPTION (provided by applicant): The characterization of integral membrane proteins is limited most by the inability to isolate such proteins in sufficient quantities. The isolation of eukaryotic membrane proteins is especially problematic. We propose to address this issue by developing a… More

DNA Polymerase Database

Award Year / Program / Phase: 2009 / SBIR / Phase II
Agency: HHS
Principal Investigator: William E. Jack
Award Amount: $497,285.00
Abstract:
DESCRIPTION (provided by applicant): This project concerns the design, construction and publication of a comprehensive database on DNA polymerases - DNAPolBase. DNAPolBase will serve as a freely available, high quality resource of DNA polymerase biochemistry, biology, genetics and structure. The… More

In vitro Reconstitution of Protein Translation of Thermus Thermophilus for Direct

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: HHS
Principal Investigator: Shaorong Chong
Award Amount: $233,095.00
Abstract:
DESCRIPTION (provided by applicant): Directed protein evolution is a powerful technology for generating proteins with desired properties, such as thermostability. There is currently no effective in vitro method to select proteins with enhanced thermostabil ity. Thermostable proteins have a wide… More

DNA Polymerase Database

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: HHS
Principal Investigator: William E. Jack
Award Amount: $107,000.00
Abstract:
DESCRIPTION (provided by applicant): This project concerns the design, construction and publication of a comprehensive database on DNA polymerases - DNAPolBase. DNAPolBase will serve as a freely available, high quality resource of DNA polymerase biochemist ry, biology, genetics and structure. The… More

NOVEL ENZYME REAGENTS FOR EPIGENETICS STUDIES.

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: HHS
Principal Investigator: Yu Zheng
Award Amount: $267,417.00
Abstract:
DESCRIPTION (provided by applicant): Epigenomics studies represent the next wave of efforts to decode the information embedded in genomes beyond the nucleotide sequences. Dynamic epigenomic changes, such as DNA methylation are key processes in cell differe ntiation, development and many pathological… More

SBIR Phase I: Synthetic respiration for improved bio-fuels production.

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: NSF
Principal Investigator: Peter R. Weigele
Award Amount: $148,960.00
Abstract:
This Small Business Innovation Research (SBIR) Phase I project will undertake engineering Escherichia coli to "breathe" (respire) using an electrode instead of oxygen. An increasing number of industrial bioprocesses use engineered E. coli strains for the production of fuels and chemicals… More

Isolation of functional IgGs in the cytoplasm of a novel E. coli expression host

Award Year / Program / Phase: 2011 / STTR / Phase I
Agency: HHS
Research Institution: CORNELL UNIVERSITY
Principal Investigator: Mehmet Berkmen – 978-380-7519
Award Amount: $213,422.00
RI Contact:
Abstract:
DESCRIPTION (provided by applicant): Monoclonal antibodies (mAbs) hold great promise in human health with applications ranging from therapeutic agents that target cancer cells, to diagnostic biomarkers that can detect trace levels of a given antigen. Thispromise is best reflected in global sales of… More

NOVEL ENZYME REAGENTS FOR EPIGENETICS STUDIES.

Award Year / Program / Phase: 2011 / SBIR / Phase II
Agency: HHS
Principal Investigator: Yu Zheng – 978-380-7441
Award Amount: $903,660.00
Abstract:
DESCRIPTION (provided by applicant): Epigenomics studies represent the next wave of efforts to decode the information embedded in genomes beyond the nucleotide sequences. Dynamic epigenomic changes, such as DNA methylation are key processes in cell differentiation, development and many pathological… More

In vitro Reconstitution of Protein Translation of Thermus Thermophilus for Direct

Award Year / Program / Phase: 2012 / SBIR / Phase II
Agency: HHS
Principal Investigator: Shaorong Chong – 978-927-5054
Award Amount: $960,499.00
Abstract:
DESCRIPTION (provided by applicant): Directed protein evolution is a powerful technology for protein engineering. It generally involves generating a library of protein variants and identifying those with desired properties by selection or screening. In terms of library complexity, in vitro selection… More

NOVEL 5-HYDROXYMETHYLCYTOSINE SPECIFIC ENZYMES FOR EPIGENETIC STUDIES.

Award Year / Program / Phase: 2012 / SBIR / Phase II
Agency: HHS
Principal Investigator: Zhenyu Zhu – 978-380-7485
Award Amount: $640,759.00
Abstract:
DESCRIPTION (provided by applicant): It is recently discovered that a significant portion of the modified cytosines in mammalian genomes is 5-hydroxymethylcytosine (5-hmC), an oxidation product of 5-methylcytosine (5-mC). Current methods including bisulfite conversion cannot distinguish or… More

FINDING NOVEL REAGENTS BY BIOINFORMATICS AND BIOCHEMISTRY

Award Year / Program / Phase: 2012 / SBIR / Phase II
Agency: HHS
Principal Investigator: Richard J. Roberts – 978-380-7405
Award Amount: $874,892.00
Abstract:
DESCRIPTION (provided by applicant): This project aims to find novel restriction enzymes that will be useful in many aspects of molecular biology research. One particular focus will be on restriction endonucleases that are able to recognize modified DNA, especially DNA containing 5-methylcytosine… More

NOVEL 5-HYDROXYMETHYLCYTOSINE SPECIFIC ENZYMES FOR EPIGENETIC STUDIES.

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: HHS
Principal Investigator: Zhenyu Zhu – 978-380-7485
Award Amount: $278,797.00
Abstract:
DESCRIPTION (provided by applicant): It is recently discovered that a significant portion of the modified cytosines in mammalian genomes is 5-hydroxymethylcytosine (5-hmC), an oxidation product of 5-methylcytosine (5-mC). Current methods including bisulfite conversion cannot distinguish or… More

FINDING NOVEL REAGENTS BY BIOINFORMATICS AND BIOCHEMISTRY

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: HHS
Principal Investigator: Richard J. Roberts – 978-380-7405
Award Amount: $218,685.00
Abstract:
DESCRIPTION (provided by applicant): This project aims to find novel restriction enzymes that will be useful in many aspects of molecular biology research. One particular focus will be on restriction endonucleases that are able to recognize modified DNA, especially DNA containing 5-methylcytosine… More

Studies of DNA Methyltransferases

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: HHS
Principal Investigator: Richard J. Roberts – 978-380-7405
Award Amount: $256,651.00
Abstract:
DESCRIPTION (provided by applicant): This project takes advantage of a DNA sequencing technology newly developed by Pacific Biosciences called SMRT sequencing. In addition to providing the DNA base sequence, this approach also allows the detection of modified bases. DNA methyltransferases have… More

Structure guided rational engineering of novel DNA reagents.

Award Year / Program / Phase: 2013 / STTR / Phase I
Agency: HHS
Research Institution: MOUNT SINAI SCHOOL OF MEDICINE
Principal Investigator: Richard D. Morgan – 978-380-7485
Award Amount: $99,781.00
RI Contact:
Abstract:
DESCRIPTION (provided by applicant): Type II restriction enzymes (REases) are indispensible tools of modern medical research. It has long been a goal of REase manufacturers to be able to offer programmable specificity enzymes, where the sequence recognizedand resulting cutting activity can be… More

Structure guided rational engineering of novel DNA reagents.

Award Year / Program / Phase: 2013 / STTR / Phase II
Agency: HHS
Research Institution: MOUNT SINAI SCHOOL OF MEDICINE
Principal Investigator: Richard D. Morgan – 978-380-7485
Award Amount: $761,592.00
RI Contact:
Abstract:
DESCRIPTION (provided by applicant): Type II restriction enzymes (REases) are indispensible tools of modern medical research. It has long been a goal of REase manufacturers to be able to offer programmable specificity enzymes, where the sequence recognizedand resulting cutting activity can be… More

Novel 5-methylcytosine Oxidases

Award Year / Program / Phase: 2013 / SBIR / Phase I
Agency: HHS
Principal Investigator: Yu Zheng – 978-380-7441
Award Amount: $251,006.00
Abstract:
DESCRIPTION: With the recent discovery of 5-hydroxymethylcytosine in mammalian DNA and the TET enzyme family responsible for its generation, it is clear that the mammalian DNA epigenome is much more complex than had been thought. A lot of questions remainto be answered about the in vivo roles and… More

Studies of DNA Methyltransferases

Award Year / Program / Phase: 2013 / SBIR / Phase II
Agency: HHS
Principal Investigator: Richard J. Roberts – 978-380-7405
Award Amount: $1,002,120.00
Abstract:
DESCRIPTION (provided by applicant): This project takes advantage of a DNA sequencing technology newly developed by Pacific Biosciences called SMRT sequencing. In addition to providing the DNA base sequence, this approach also allows the detection of modified bases. DNA methyltransferases have… More