There is a considerable amount of research which indicates that high frequency jet ventilation (hfjv) is an effective method for maintaining respiratory function. with this typeof approach, the normal tidal volume inspiration/expiration cycle is replaced with a small high frequency oscillatory flow… More

The objective of this program is to develop an electrical connector/cable concept applicable to a wide variety of implanted medical devices. these would be made available tooriginal manufacturers of clinical devices and to institu- tions engaged in experimental research. in the phase i program, the… More

Mechanical ventricular assistance has proven to be an effective treatment in the management of cardiogenic shock following open heart surgery and myocardial infarction. promise for its use as a bridge to cardiac transplantation has been demonstrated. intra-aortic balloon counterpulsation is the… More

In emergency airway management, effective resuscitation may be compromised by the time available to perform intubation or tracheostomy procedures. these procedures require a highlevel of training and competence. this research plan proposes to design and develop a small bore airway access device that… More

The long-term objective of this project is to develop and market an anatomically compatible chronic ventricular assistsystem (vas) based on a direct motor-driven axial-flow blood pump. the specific aim of the phase i research is to demonstrate the mechanical integrity and blood seal performance… More

The long-term objective of the research is to create an implantable temporary right ventricular assist system (rvas)that is superior to existing devices with respect to size, surgical complexity, ease of use, and cost. approximately 30 percent of ventricular assist applications involve a rvas.… More

A unique design concept for miniature axial flow blood pumps is presented that requires no center bearing structure. there is no rotating seal or requirement for a purge fluid. the implanted pump/motor has a volume of 36 cc and weighs approximately 120 gm. very preliminary tests of several different… More

A widely recognized problem in pediatric cardiac surgery is the lack of suitable mechanicalcirculatory support devices. In this Phase I program, rotary pump technology will be utilized for a bloodpump system specifically intended for neonatal/pediatric (N/P) use. This device incorporates a… More

We have a long-term objective of bringing to clinical practice a system that can preserve donor heahours prior to transplantation. This length of preservation time compares to a 4-5 hour limit associtechnology. Such a significant extension of time would be beneficial because better hostorgan… More

We have made significant progress in development of an implantable axial flow blood pump intended fcirculatory support. As a result, prototype designs of the pump, its cannulae, and a console based cformal qualification testing. One element which remains to be developed is a portable, wearable… More

We will develop an integrated blood pump-membrane oxygenator/heat exchanger suitable for cardiopulmbypass in patients < 5 kg body weight. This device will feature Nimbus' new pediatric/neonatal centrsystem. Effective blood oxygenation and heat transfer will be accomplished via a microporous… More

One problem facing cardiac surgeons is lack of suitable devices to provide temporary cardiacsupport to neonates and pediatric aged patients. Existing devices used clinically (ECMO and centrifugalpumps) are too large relative to the size of the patient. The specific aims of this program focus… More

Advances in ventricular assist device (VAD) technology during the last decade have been largely limconcepts intended for the adult population. Options for mechanical support of pediatric patients witand especially those who are awaiting cardiac transplantation, are extremely limited. The primary… More