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Evaluate Therapeutic Potential of Novel Immunomodulator, Imprime

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
96390
Program Year/Program:
2010 / SBIR
Agency Tracking Number:
N43CO201000118
Solicitation Year:
N/A
Solicitation Topic Code:
NCI
Solicitation Number:
N/A
Small Business Information
BIOTHERA
BIOTHERA 3388 MIKE COLLINS DR EAGAN, MN 55121-2410
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2010
Title: Evaluate Therapeutic Potential of Novel Immunomodulator, Imprime
Agency: HHS
Contract: N43CO201000118
Award Amount: $159,140.00
 

Abstract:

Pancreatic cancer is a "rare" and fata l disease, with few treatment options. Currently, promising antitumor strategies utilize combination therapies, with each agent targeting separate aspects of oncogenesis. Disappointingly, combination of anti- EGFR monoclonal antibody (MAb), cetuximab, with standard-of-care, gemcitabine, failed to improve survival in this disease. Although EGFR is over-expressed in >90% of pancreatic carcinomas -90% also contain KRAS mutations. We herein propose a strategy that could overcome resistance of KRAS mutations to anti-EGFR MAbs. Biothera is developing Imprime-PGG¿, a beta 1,3/1,6 glucose polymer, as an adjunct to MAbs for cancer treatment. The proprietary agent, Imprime, induces neutrophil-mediated cellular cytotoxicity, where Imprime 'primes' neutrophils (comprise -50%-70% of human immune cells) to recognize and kill MAb targeted tumors. Preclinically, Imprime has shown therapeutic efficacy as an adjunct to MAbs in various tumor models, including KRAS-mutated lung and colon carcinoma models. This coupled wi th the safety and recent efficacy data from a Phase 1 b/2 metastatic CRC study supports Imprime to be a safe and effective drug. Overall objective is to establish preclinical proof of concept for this novel treatment approach in pancreatic cancer xenografts; both KRAS-wild type and KRASmutant tumors will be studied, and subsequently evaluate therapeutic potential in the clinic.

Principal Investigator:

Mary Antonysamy
Small Business Information at Submission:

BIOTHERA
BIOTHERA 3388 MIKE COLLINS DR EAGAN, MN 55121-2410

EIN/Tax ID: 411881351
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No