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Photochemical Tissue Bonding for Military Medical Applications

Award Information

Agency:
Department of Defense
Branch:
Air Force
Award ID:
83384
Program Year/Program:
2007 / STTR
Agency Tracking Number:
F074-033-0346
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
nLight Photonics
5408 NE 88th Street, Bldg E Vancouver, WA -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2007
Title: Photochemical Tissue Bonding for Military Medical Applications
Agency / Branch: DOD / USAF
Contract: FA9550-07-C-0098
Award Amount: $99,824.00
 

Abstract:

Joining severed vessels is a recurring problem in trauma and surgery. The basic technology that uses suture has been available for a long time. Many technologies have been introduced to make vessel suturing water-tight. Any solution to this problem must integrate well with standard medical care. This means that the solution must be safe, effective, acceptable to surgeons, and technologically feasible. We propose a novel two-wavelength laser that allows precise and rapid closure of anastomosis of vessels. An exogenous glue, composed of FDA-approved human serum albumin will be used to increase bond strength and burst pressures. A dissolvable stent, also composed of human serum albumin, will be used to facilitate joining larger vessels and aligning the vessel edges. Laser bonding has not gained widespread clinical acceptance because (1) an exogenous chromophore (indocyanine green) was required, (2) no economical laser sources, (3) large laser beam sizes (4) no internal support for the vessel during anastomosis was available. Advances in laser technology at nLight Corp remove issues (2) and (3). The protocol proposed would eliminate issues (1) and (4) - albumin replaces indocyanine green, and internal support is provided by a solid albumin stent, which dissolves once blood is allowed to flow again.

Principal Investigator:

Paul Crump
Principal Scientist
3607135161
paul.crump@nlight.net

Business Contact:

Ross Lancaster
Program Manager
3606246188
ross.lancaster@nlight.net
Small Business Information at Submission:

NLIGHT PHOTONICS
5408 NE 88th Street, Bldg E Vancouver, WA 98665

EIN/Tax ID: 912066376
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
OREGON MEDICAL LASER CENTER
9205 SW Barnes Road
Portland, OR 97225
Contact: Scott A. Prahl
Contact Phone: (503) 216-2197
RI Type: Domestic nonprofit research organization