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Development of a Multi-analyte Biosensor Platform Based on…

Award Information

Agency:
Department of Homeland Security 		Branch:
N/A 		Award ID:
69239 		Program Year/Program:
2004 / SBIR
Agency Tracking Number:
04110240 		Solicitation Year:
2004 		Solicitation Topic Code:
H-SB04.1-002 		Solicitation Number:
N/A
Small Business Information
Nomadics, Inc.
1024 S. Innovation Way Stillwater, OK 74074
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2004
Title: Development of a Multi-analyte Biosensor Platform Based on Computationally-Designed Proteins
Agency: DHS
Contract: NBCHC040077
Award Amount: $99,995.00
 

Abstract:

Antibody-based receptor scaffolds used in chemical and biological sensors suffer from certain inherent shortfalls. We propose an approach based on the use of computationally designed proteins as receptor scaffolds. Such receptor scaffolds overcome many of the problems encountered with antibodies. This approach offers the significant advantage of being a general method that provides a path to rapid development of specific receptors. We propose to transition fluorescent reagentless biosensor technologies from the academic laboratory in which they were originally developed into fieldable products. Specifically, we intend to develop biosensors that incorporate engineered periplasmic binding proteins (PBPs) that recognize and report organophosphate mimics and hydrolysis products of well-known nerve agents such as Soman (organophosphate surrogate is pinacolyl methylphosphonic acid, or PMPA) and Sarin (organophosphatesurrogate isopropyl methyl phosphonic acid, or IMPA). This work will initially proceed as a collaboration between Nomadics and the laboratory of Dr. H.W. Hellinga at Duke University Medical Center. Dr. Hellinga has developed PMPA-binding PBPs and is finishing development of IMPA-binding PBPs.

Principal Investigator:

Martin Leuschen
Principal Investigator
4053729535
mleuschen@nomadics.com

Business Contact:

Bob Hilley
4053729535
bhilley@nomadics.com
Small Business Information at Submission:

Nomadics, Inc.
1024 S. Innovation Way Stillwater, OK 74074

EIN/Tax ID: 731443947
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No