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Multiplexed Immunological Assay on Micro-ring Resonators for Detection of Brain…

Award Information

Agency:
Department of Defense
Branch:
Office of the Secretary of Defense
Award ID:
76635
Program Year/Program:
2005 / STTR
Agency Tracking Number:
O054-003-2029
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Nomadics, Inc.
1024 S. Innovation Way Stillwater, OK 74074
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2005
Title: Multiplexed Immunological Assay on Micro-ring Resonators for Detection of Brain Injury-Specific Biomarkers
Agency / Branch: DOD / OSD
Contract: W81XWH-05-C-0174
Award Amount: $100,000.00
 

Abstract:

The goal of the proposed research is to develop a highly sensitive, high-throughput, and miniaturized assay system for rapid detection of brain injury-specific biomarkers in serum. The assay will be integrated into a portable detector so results can be immediately communicated to the health-care provider for assessment and appropriate treatment of patient injury. This technology will be particularly important on the battlefield where sophisticated and expensive laboratory analytical equipment and expertise is not readily available. The key technological innovation for this project is called a micro-ring resonator, which undergoes a measurable change in resonant wavelength when light interacts with absorbed mass, such as bio-targets binding to a recognition moiety, on the micro-ring surface. In Phase I, three serum biomarkers for brain injury, S100B, NSE, and GFAP, will be detected using an immunologic assay on the micro-ring surface. To develop this platform, Nomadics proposes to use these high finesse micro-rings that incorporate a novel high index material, HydexT, to develop stable and versatile biophotonic interfaces based on label-free and reagentless immunologic platforms, to provide multiplexing capabilities for high-throughput testing and referencing, and to integrate these into a portable and cost-effective sensor platform.

Principal Investigator:

Jean Clarke
Principal Invest./Microbiologist
4053729535
jclarke@nomadics.com

Business Contact:

Jim Luby
Chief Operations Officer
4053729535
jluby@nomadics.com
Small Business Information at Submission:

Nomadics, Inc.
1024 S. Innovation Way Stillwater, OK 74074

EIN/Tax ID: 731443947
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
MASSACHUSETTS GENERAL HOSPITAL
Alzheimer's Disease Rsrch Unit, 114 16th Street (Rm 2850)
Charlestown, MA 02129
Contact: Brian J. Bacskai
Contact Phone: (617) 724-5306
RI Type: Domestic nonprofit research organization