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3D Scaffold and Stem Cell Based Bioengineered Skin for Treatment of Cutaneous…

Award Information

Department of Defense
Office for Chemical and Biological Defense
Award ID:
Program Year/Program:
2007 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
Nomadics, Inc.
1024 S. Innovation Way Stillwater, OK 74074
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 2
Fiscal Year: 2007
Title: 3D Scaffold and Stem Cell Based Bioengineered Skin for Treatment of Cutaneous Vesicant Injury
Agency / Branch: DOD / CBD
Contract: W81XWH-05-C-0128
Award Amount: $846,163.00


In this Phase II project Nomadics will novate our research to a spin-out company Nico Technologies. Nomadics will remain a subcontractor during this transition. The team proposes a new treatment for injuries from mustard gas based on biodegradable inverted colloidal crystal scaffolds impregnated with stem cells. Phase I results demonstrated excellent performance of these scaffolds for differentiation of murine embryonic stem cells into skin cell lines. By the end of Phase II, we expect to have enhanced scaffold manufacturing and performed in-vitro optimization of ESC differentiation. We will test cell-free scaffolds for tissue regeneration and develop a preservation protocol. Mice will be tested at the University of Texas Medical Branch for the treatment of mustard gas injuries. The team offers a unique technology proven to be an exceptionally convenient media for stem cell differentiation. A novelty of this approach to vesicant injury treatment is its use of three stem-cell sources: embryonic stem cells, adult stem cells from discarded tissue, and recruitment of the patient's own stem cells by growth-factor-loaded scaffolds. Our team has a long history of successful collaborative projects. Team member J. Cortiella's experience with treatment of military burn victims brings knowledge of the real-life problems in combat situations.

Principal Investigator:

R. C. Doty

Business Contact:

James Luby
Chief Operations Officer
Small Business Information at Submission:

1024 S. Innovation Way Stillwater, OK 74074

EIN/Tax ID: 731443947
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No