Description (provided by applicant): Development of novel biomedical sterilization technology is proposed. The method utilizes supercritical C02, which allows for the sterilization of materials that are incompatible with current methods. This technology can be applied to a variety of… More

DESCRIPTION (provided by applicant): Terminal sterilization of tendon allografts to the same levels called for in medical devices is currently all but non-existent. Terminal sterilization using ethylene oxide gas leaves toxic residues and negatively impacts the probability of positive outcomes… More

DESCRIPTION (provided by applicant): A new method of bone tissue terminal sterilization using supercritical CO2 is proposed for accomplishing industrially acceptable levels of bacterial inactivation. Preliminary experiments reveal that unlike gamma-irradiation, supercritical CO2 does not reduce the… More

DESCRIPTION (provided by applicant): The direct result of phase I funding has been the development of a viable bone allograft terminal sterilization technology that will, for the first time, allow tissue banks to easily process bone tissue to a sterility assurance level equal to that called for in… More

This Small Business Innovation Research (SBIR) Phase I research project aims to develop a novel method for the production of whole cell vaccines using the supercritical CO2 technology. The majority of current whole cell vaccine preparations are made using formalin inactivation which has numerous… More

DESCRIPTION (provided by applicant): Currently, most tissue banks use a two step process to sterilize soft tissue allografts. The initial step reduces the bioburden with the second step in sterilization resulting in terminal sterilization . The direct res ult of Phase 1 funding has been the… More

DESCRIPTION (provided by applicant): Over the past several decades there has been relatively little innovation in the arena of medical device sterilization. Ethylene oxide (ETO) and gamma irradiation (3-irradiation) are the only technologies currently available for medical devices. In particular,… More

DESCRIPTION (provided by applicant): Over the past several decades there has been relatively little innovation in the arena of medical device sterilization. Ethylene oxide (ETO) and gamma irradiation ( irradiation) are the only technologies commerciallyavailable for medical devices. In particular,… More