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THE SUCCESSFUL RADIATION THERAPY OF CANCER DEPENDS UPON THE THERAPEUTIC RATIO;…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
3092
Program Year/Program:
1985 / SBIR
Agency Tracking Number:
3092
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Nuclear Oncology Service Corp.
1725 W. Harrison St. Suite 802 Chicago, IL 60612
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1985
Title: THE SUCCESSFUL RADIATION THERAPY OF CANCER DEPENDS UPON THE THERAPEUTIC RATIO; THE RADIATION RESPONSE OF THE TUMOR COMPARED TO NORMAL TISSUES.
Agency: HHS
Contract: N/A
Award Amount: $46,918.00
 

Abstract:

THE SUCCESSFUL RADIATION THERAPY OF CANCER DEPENDS UPON THE THERAPEUTIC RATIO; THE RADIATION RESPONSE OF THE TUMOR COMPARED TO NORMAL TISSUES. THROUGH THE USE OF PENETRATING BEAMS AND FRACTIONATED SCHEDULES THE ACUTE EFFECTS HAVE BEEN REDUCED; HOWEVER, THE LATE RESPONSE OF TISSUES, PARTICULARLY FIBROSIS, REMAINS AS A COMPLICATION. THERE IS LITTLE QUANTITATIVE INFORMATION ON THE DEVELOPMENT OF RADIATION INDUCED FIBROSIS AFTER SINGLE OR FRACTIONATED DOSES. IN THE PAST TWO YEARS METHODS HAVE BEEN DEVELOPED TO ASSAY FIBROTIC CHANGES IN TISSUES. TO TEST THE FEASIBILITY OF USING THESE ASSAYS TO MEASURE FRACTIONATED INDUCED FIBROSIS, ANIMALS WILL BE IRRADIATED UNDER THE FOLLOWING CONDITIONS: SINGLE DOSE, ANESTHETIZED AND PARTIAL BODY SHIELDED; LIMB SHIELDED; OR SEVERAL FRACTIONATED SCHEDULES IN UNANESTHETIZED MICE. FOUR MONTHS AFTER EXPOSURE THE SYNTHESIS OF COLLAGEN IN SKIN AND LUNG WILL BE MEASURED BY THE INCORPORATION OF 3H-PROLINE INTO OH-PROLINE (AN AMINO ACID ESSENTIALLY UNIQUE TO COLLAGEN). TOTAL COLLAGEN CONTENT WILL BE MEASURED IN FIXED, PARAFFIN-EMBEDDED TISSUES FROM THE SAME ANIMALS. THE RESULTS FROM THESE STUDIES WILL DEMONSTRATE WITHIN 6 MONTHS THE FEASIBILITY OF USING THE ASSAY SYSTEMS AND THE RADIATION SCHEDULES TO RAPIDLY MEASURE FRACTIONATED, RADIATION INDUCED FIBROSIS.

Principal Investigator:

Frank hendrickson
PRINCIPAL INVESTIGATOR
3129425755

Business Contact:

Small Business Information at Submission:

Nuclear Oncology Service Corp.
1725 W. Harrison St. Suite 802 Chicago, IL 60612

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No