And d-myoinositol-1,4,5-triphosphate and their analogs the long-term objective of this proposal are: (1) to develop a general method for the synthesis of phosphatidyl- d-myoinositol-4,5-bisphosphate [ptdins(4,5)p2] as a key material for the preparation of d-myo-inositol-1,4,5- triphosphate… More

Evidence is accumulating that dietary supplementation with fish oil triglycerides is a potentially attractive prophyl- actic and therapeutic tool for coronary vascular disease. it may also be useful for immune and other disorders respon-sive to modulation of eicosanoid cascade and eicosanoid… More

There is a current and growing interest in the role of membrane phosphoinositides in cell biology, especially in relation to the transmission of ca2+ mediated signals. these signals are generated when cell-surface receptors are activated by hormones, neurotransmitters, growth factors, and other… More

The overall objective of this study is to develop a simple, general, and practical method for resolving derivatives of dl-myo-inositol into d- and l-enantiomers. a novel approachbased on putative enantioselective hydrolysis catalyzed by hydrolase enzymes is suggested. the pure enantiomers are… More

Studies on the design, preparation, characterization, and enzymology for the sphingolipid analogues (spis) of the phosphoinsitides will be performed. the parent structure incorporates sphingosine (sn) esterified to the 1-phosphate of an inositol-1-phosphate, and is formally derived by replacement of… More

The phosphoinositide-specific phospholipase C (PI-PLC) and the phosphatidylinositol 3-kinase (PI3-kinase) are key enzymes in the intracellular signal transduction pathway. These enzymes utilize thephosphoinositides, in particular phosphatidylinositol-4,5-bisphosphate [PI (4,5)P2] as… More

The recently discovered enzyme phosphatidylinositol 3-kinase (PI 3- kinase) physically associates with and is phosphorylated by activated growth factor receptors and oncogenes which manifest protein-tyrosine kinase activity. It phosphorylates phosphatidylinositols specifically at the D-3-hydroxyl to… More

Not Available Development of an economical tunable high performance filter for high power RE' applications is particularly important for the elimination of cosite interference from clustered SINCGARS radio transmitters. Paratek's new low-loss voltage-tunable dielectrics made from ferroelectric… More

Not Available PCA proposes conducting research towards a software system to analyze test program set (TPS) source code and extract, synthesize, and analyze test parameters, interface characteristics, and switching requirements. It will then compare this data against an interface specification… More

Description: (Applicant's abstract): Inositolphospholipids are an important group of biological amphiphilic phospholipids. The group includes phosphatidylinositols (PtdIns) and its radyl and sphingo analogues. Members of the group are critical intracellular… More

Description: (Applicant's abstract): Inositolphospholipids are an important group of biological amphiphilic phospholipids. The group includes phosphatidylinositols (PtdIns) and its radyl and sphingo analogues. Members of the group are critical intracellular… More

DESCRIPTION (provided by applicant): The cellular phosphoinositides, including the phosphatidylinositols and their mono- and polyphosphate derivatives, are critical in intracellular signaling and related cascades. We have developed methods for synthesizing analogs of the… More