We have developed an innovative lensless optical power limiting system for green region exploiting photoanisotropy of azobenzene films for low power continuous wave and high power nanosecond pulsed lasers (also with picosecond in solutions). It is a promising technique for next generation laser eye… More

We have developed an innovative lensless optical power limiting system for green region exploiting photoanisotropy of mesoporous films for low power continuous wave and high power nanosecond pulsed lasers. In Phase I, nanosecond response time has been obtained by the MesoPAD system we proposed. It… More

DESCRIPTION (provided by applicant): This NIH SBIR program intends to develop triblock copolymer coated quantum dot (QD) and adaptor protein G fragment bioconjugates as fluorescent probes for biomedical applications. The strategy and design of this project are based on our recent success in the… More

This Small Business Innovation Research Phase I project will synthesize cadmium-free, water-soluble, and multicolor quantum dots (QDs) by chemical doping, which can be used as fluorophores in the fields of biology and biomedicine. As the popularity of QD labeling soars, concerns are raised on the… More

This Small Business Innovation Research (SBIR) project is to develop affordable multicolor nanocrystals emitters for optoelectronic application. Semiconductor nanocrystals have been considered with potential applications in many fields. However, they have faced some challenges regarding their… More

This Small Business Technology Transfer Phase I research demonstrates the feasibility to use the new generation of oxide magnetic nanoparticles for rapid and high efficient separation of foodborne pathogens. Rapid detection of foodborne pathogens is urgently needed to ensure food safety and… More

DESCRIPTION (provided by applicant): Since semiconductor nanocrystals [quantum dots (QDs)] have been adopted as a new class of fluorescent labels, many studies have indicated a broad range of potential applications using QDs as new probes in vivo and in vi tro imaging. Because of QDs long lifetimes… More

This NSF Small Business Innovation Research Phase II project is to synthesize cadmium-free, water-soluble, and multicolor quantum dots (QDs) by chemical doping. The project will focus on the synthesis of high quality doped ZnSe QDs using a newly developed phosphine-free approach. From these cadmium… More

DESCRIPTION (provided by applicant): Enriched abnormal cells will enable genomic, proteomic, and epigenomic analyses to detect cancer-specific alterations in expressed genes, protein/peptide profiles, and epigenetic markers. The ability to carry out such e nrichment in high efficiency in a routine… More

DESCRIPTION (provided by applicant): Enriched abnormal exfoliated cells and biomolecules will enable genomic, proteomic, and epigenomic analyses to detect cancer-specific alterations in expressed genes, protein/peptide profiles, and epigenetic markers. The ability to carry out such enrichment and… More

Iron oxide magnetic nanoparticles with high magnetization value and well controlled size and surface chemistry are currently under intense study due to their broad applications in biomedical research. Recent advances in iron oxide synthesis in organic solv ents at elevated reaction temperature… More

DESCRIPTION (provided by applicant): NIH Phase I Quantum dots and Magnetic nano-particles for Ante-mortem Diagnostics of m Prion Infection Ocean Nano Tech proposes to develop a portable, rapid, sensitive, high throughput, inexpensive, and easy to use syste m for the ante-mortem diagnosis of prion… More

DESCRIPTION (provided by applicant): The presence of Her-2, estrogen receptor (ER) or progesterone receptor (P) on breast cancer cells is a very important biomarker which facilitates physicians in making decisions on treatment schemes and in proposing prog nosis of the disease. Current methods for… More

DESCRIPTION (provided by applicant): This NIH SBIR project intends to develop a new generation of iron oxide nanoparticles as target specific MRI contrast agents for early detection of breast cancer. Recent advances in iron oxide synthesis in organic solve nts at elevated reaction temperature allow… More

DESCRIPTION (provided by applicant): The goal of this SBIR project is to develop a multiplexing method to simultaneously quantify the expression levels of biomarkers in heterogeneous tumor tissue. The current method for diagnostic and prognostic classifica tions of biomarkers is based on… More

DESCRIPTION (provided by applicant): Ocean NanoTech proposes to develop a portable, sensitive, high throughput, low cost, and user friendly system for the early stage diagnosis of ovarian cancer using magnetic nanoparticles (MNPs), quantum dots (QDs), and a nanoelectrode array (NEA) all integrated… More

Quantum dots (ODs) with unique optical properties such as size-tunable emission , simultaneous excitation,  high brightness, and very slow photobleaching ¿can be used as powerful cancer diagnostic tools providing the  -"'¿cile-cular¿ profiles of cancer cases based… More

This Small Business Technology Transfer Research Phase I project will develop high-efficiency two-photon lasers based on microbeads doped with colloidal quantum dots (QDs) for applications in coherent-optical coding. Current two-photon lasing materials are generally organic dyes which exhibit fast… More

This Small Business Innovation Research Phase I project proposes to demonstrate the feasibility of using nanoparticles as an adjuvant for enhanced antibody production. A number of adjuvants are commercially available for use in animals to boost antibody production, but most of them pose potential… More

DESCRIPTION (provided by applicant): Our goal is to develop easy to use, inexpensive, and sensitive quantum dots beads (QDBs) based strip test for multiplex diagnosis of human malaria infection called MAL-QDBTest that can detect as low as 1 parasite/uL ina lt 20 min assay. The MAL-QDBTest consists… More

DESCRIPTION (provided by applicant): Chest pain in patients presenting to the emergency department (ED) present a clinical dilemma: transfer for emergent coronary revascularization, admit overnight for cardiac telemetry and stress testing, or discharge home with medical follow-up. In this proposal,… More

Breast cancer is the most common type of cancer and the second leading cause of cancer death among women with more than one million new cases and 370,000 deaths worldwide yearly. Chemotherapy drugs, such as Doxorubicin, have been used in both pre- and post-operative adjuvant therapy or as the main… More

The goal of this project is to develop multiple-biomarker imaging for detection of human papillomavirus (HPV) associated human cancer. Quantum dots (QDs) with multiple emission colors were chosen as optical probes to label the biomarkers on tissue. Attribute to the unique optical properties of… More