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Development of Cadmium-free and Multicolor Quantum Dots as Lifetime Imaging…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
88930
Program Year/Program:
2008 / SBIR
Agency Tracking Number:
CA134091
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2008
Title: Development of Cadmium-free and Multicolor Quantum Dots as Lifetime Imaging Probe
Agency: HHS
Contract: 1R43CA134091-01
Award Amount: $174,596.00
 

Abstract:

DESCRIPTION (provided by applicant): Since semiconductor nanocrystals [quantum dots (QDs)] have been adopted as a new class of fluorescent labels, many studies have indicated a broad range of potential applications using QDs as new probes in vivo and in vi tro imaging. Because of QDs long lifetimes (10s of ns) compared to organic fluorophores (1-5 ns), QDs can be used as new fluorescence lifetime imaging probes to reduce cells and tissue's autofluorescence background (2-4 ns). This NIH SBIR project will focu s on developing a new generation of cadmium-free, water-soluble multicolor QDs for lifetime imaging to eliminate the autofluorescence for in vitro QD-imaging of biomarkers in tumor cells and tissue sections. A key feature of this new approach is to tune QD emission color by doping the QD core with a third element rather than changing the particle sizes. This kind of new type doped QDs should bring wide interest in the applications of fluorescence labeling due to long lifetime emissions from doped ion itself and possible high emission efficiency by QDs as donors and doped ions as accepters. The doped core/shell QDs would be converted to water soluble and biocompatible for the potential biomedical applications in the field of real-time imaging.

Principal Investigator:

Business Contact:


AWANG@OCEANNANOTECH.COM
Small Business Information at Submission:

OCEAN NANOTECH, LLC
OCEAN NANOTECH, LLC 2143 Worth Lane SPRINGDALE, AR 72764

EIN/Tax ID: 270097569
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No