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SBIR TOPIC 252 - MAGNETIC IRON OXIDE NANOPARTICLES FOR IMAGING ENHANCER

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
94154
Program Year/Program:
2008 / SBIR
Agency Tracking Number:
N43CO0800062
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2008
Title: SBIR TOPIC 252 - MAGNETIC IRON OXIDE NANOPARTICLES FOR IMAGING ENHANCER
Agency: HHS
Contract: N43CO0800062
Award Amount: $149,991.00
 

Abstract:

Iron oxide magnetic nanoparticles with high magnetization value and well controlled size and surface chemistry are currently under intense study due to their broad applications in biomedical research. Recent advances in iron oxide synthesis in organic solv ents at elevated reaction temperature allows the preparation of size tunable and monodisperse particles. This NIH SBIR project intends to develop this new generation of iron oxide nanoparticles as target specific MRI contrast agents for pancreatic cancer d etection. The specific aims are: 1) Prepare iron oxide nanoparticle kits with various surface ligands (such as COOH, NH2, biotin, streptavidin, and IgG) for target specific MR1 imaging. The amount of the functional groups on each nanoparticles will be qua ntified. 2) Optimize the size and surface coating of the iron oxide nanoparticles for increased contrast and reduced non-specific uptake by liver/spleen/ macrophages. The 5 nm, 10 nm, 20 nm and 30 nm iron oxide nanoparticles will be chosen for the size de pendent study, the optimized iron oxide nanoparticles will be coated with the different amount of PEG to reduce RES uptake. 3) Investigate specificity and sensitivity of ATF-iron oxide nanoparticles in tumor imaging using orthotopic mouse pancreatic tumor xenograft models. We conduct preclinical studies to determine the optimal components and conditions for applying ATF 10 nanoparticles for the detection of pancreatic cancer in vivo.

Principal Investigator:

Andrew Wang

Business Contact:


AWANG@OCEANNANOTECH.COM
Small Business Information at Submission:

OCEAN NANOTECH, LLC
OCEAN NANOTECH, LLC 2143 Worth Lane SPRINGDALE, AR 72764

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No