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DIFFERENTIAL THERMOMETRIC BIOANALYTICAL SENSOR (DTBS)

Award Information

Agency:
National Science Foundation
Branch:
N/A
Award ID:
11832
Program Year/Program:
1990 / SBIR
Agency Tracking Number:
11832
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Ohmicron Corp.
375 Pheasant Run Newtown, PA 18940
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1990
Title: DIFFERENTIAL THERMOMETRIC BIOANALYTICAL SENSOR (DTBS)
Agency: NSF
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

BIOSENSORS ARE A RAPIDLY EMERGING BIOTECHNOLOGY ENGINEERING EFFORT THAT IS MULTIDISCIPLINARY, ENCOMPASSING MANY TYPES OFMEASURING TECHNIQUES AND DEVICES. WE PROPOSE TO EXPLORE THEFEASIBILITY OF DEVELOPING A SENSITIVE, MINIATURE DIFFERENTIAL THERMOMETRIC BIOSENSOR DEVICE USING THIN POLYMER FILMS (POLYVINYLIDENE FLUORIDE OR PVDF) DISPLAYING A PYROELECTRIC RESPONSE. BY UTILIZING SUCH TECHNIQUES AS PHOTOLITHOGRAPHIC ETCHING, ELECTROCHEMICAL POLYMERIZATION AND MICROPROCESSOR BASED DATA ACQUISITION AND ANALYSIS, WE ANTICIPATE CONSTRUCTING AND EVALUATING A SIMPLE ENZYME AND IMMUNOCHEMICAL BASED BIOSENSOR DEVICE WHICH IS SENSITIVE, QUANTITATIVE AND INCORPORATING LOW COST FABRICATION TECHNIQUES. A DISTINCT ADVANTAGE OF A THERMOMETRIC BIOSENSOR DEVICE IS THAT A WIDE RANGE OF ANALYSES CAN BE PERFORMED AND THE SPECIFICITY DETERMINED BY THE CHOICE OF BIOLOGICAL PROCESSES WITHOUT THE POTENTIAL OF INTERFERENCES ENCOUNTERED BY METHODS SUCH A SPECTROPHOTOMETRY OR FLUOROMETRY. FURTHER, UNLIKE CALORIMETRIC TECHNIQUES USING THERMISTORS OR THERMOPILES, PYROELECTRIC FILMS CAN BE FABRICATED TO EXTREMELY CLOSE PHYSICAL TOLERANCES BY SIMPLE MEANS AND OPERATED IN A DIFFERENTIAL MODE, IRRESPECTIVE OF THE ABSOLUTE TEMPERATURE. IN EFFECT, WE PROPOSE TO EVALUATETECHNIQUES THAT CAN SIGNIFICANTLY IMPROVE UPON AND SIMPLIFY THE CLASSICAL METHODS OF THERMOMETRY AND MICROCALORIMETRY.

Principal Investigator:

Mark Kent Malmros
Cto
0

Business Contact:

Small Business Information at Submission:

Ohmicron Corp
375 Pheasant Run Newtown, PA 18940

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No