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PROTEIN KINASE C IS ACTIVATED BY TUMOR PROMOTORS AND THERE IS STRONG EVIDENCE…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
4766
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
4766
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ONCOGENE SCIENCE, INC.
106 CHARLES LINBERGH BLVD Uniondale, NY 11553
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1986
Title: PROTEIN KINASE C IS ACTIVATED BY TUMOR PROMOTORS AND THERE IS STRONG EVIDENCE THAT IT ACTUALLY MEDIATES TUMOR PROMOTION.
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

PROTEIN KINASE C IS ACTIVATED BY TUMOR PROMOTORS AND THERE IS STRONG EVIDENCE THAT IT ACTUALLY MEDIATES TUMOR PROMOTION. ACTIVATED PROTEIN KINASE C PHOSPHORYLATES THE EPIDERMAL GROWTH FACTOR RECEPTOR GUANYLATE CYCLASE AND SEVERAL OTHER POTENTIALLY REGULATORY PROTEINS; THE PHYSIOLOGICAL SIGNIFICANCE OF THIS PHOSPHORYLATION IS UNDER STUDY IN A NUMBER OF LABORATORIES. IN PHASE I, ONCOGENE SCIENCE WILL (1) DETERMINE THE SUBSTRATE SPECIFICITY OF PROTEIN KINASE C FOR DEFINED SYNTHETIC PEPTIDES; (2) PRODUCEANTIBODIES AGAINST THE OPTIMIZED PEPTIDE SUBSTRATE; (3) SYNTHESIZE INHIBITORS OF PROTEIN KINASE C; (4) DEVELOP SPECIFIC ASSAYS FOR PROTEIN KINASE C-CATALYZED PHOSPHORYLA- TION; AND (5) DEVELOP FLUORESCENT PEPTIDES TO VISUALIZE PROTEIN KINASE C IN CELLS. THE RESULTS OF PHASE I RESEARCH WILL POINT THE WAY TOWARD DESIGN OF A SERUM-BASED DIAGNOSTICASSAY FOR PROTEIN KINASE C AND WILL POTENTIALLY LEAD TO DEVELOPMENT OF POTENT INHIBITORS OF PROTEIN KINASE C. THESEINHIBITORS OF TUMOR PROMOTION COULD BE HIGHLY BENEFICIAL. PROTEIN KINASE C INHIBITORS MIGHT ALSO HAVE APPLICATION IN THE AREAS OF CANCER TREATMENT, IMMUNOMODULATION, AND CANCER RESEARCH.

Principal Investigator:

Fred h reynolds jr
PRINCIPAL INVESTIGATOR
5168772882

Business Contact:

Small Business Information at Submission:

Oncogene Science Inc
222 Station Plaza North Suite 330 Mineola, NY 11501

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No