It is clear from a number of studies throughout the world that human papillomavirus (hpv) infection of the female genital tract is a significant risk factor in the development of cervical cancer. since hpv can be present innormal tissue showing no pathology, perhaps as a latent viral infection, we… More

Recent molecular virologic and immunologic studies have shown a relationship between human papillomavirus (hpv) infection and dysplasia of the uterine cervix. the significance of these observations is underscored by the fact that dysplasias are considered precursor lesions to cervical cancer. the… More

Formalin-fixed, paraffin-embedded tumor tissue blocks from cancer patients are stockpiled in pathology labs throughout the world. these tissue blocks contain the secrets of oncogenes, their relationship to carcinogenesis, and their response to therapy. the overall aim of this proposed project is to… More

Diagnosis of numerical chromosome abnormalities is almost invariably based on the evaluation of mitotic chromosome compliments using chromosome banding to facilitate individual chromosome identification. chromosome analysis has become a major diagnostic tool in many areas of medicineincluding… More

Advances in molecular biology have fostered a new investigational area. the analysis of cellular dna for oncogenic segments, latent viruses, polymorphisms, gene amplification, and rearrangements has permitted researchers to establish meaningful relationships between events at the dna and rna level… More

Molecular cytogenetics is having a major impact on chromosome analysis in research and clinical diagnostic laboratories. DNA amplification events in solid tumors are proving to be important prognostic variables in human cancers. Development of probes to observe these amplifications utilizing… More

Cytogenetic analysis is an important diagnostic laboratory tool in medical genetics, oncology, and genetic research. nearly one in every 150 newborns is affected with a chromosome defect that requires analysis and evaluation by a clinical cytogenetics service. an equivalent caseload comes from both… More

Normal cell death regulates tumor and normal tissue kinetics, and its suppression may beassociated with prognosis and diagnosis of cancer. Apoptosis is the normal physiological process ofselective cell elimination entailing preprogrammed responses to physiological inducers and to a widespectrum of… More

Molecular cytogenetics has had a major impact on chromosome analysis in both research and clinical laboratories. telomeres, together with the centromere, define the physical limits of each chromosome. chromosome-specific centromere probes are presently available. these probes, in conjunction with… More