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MOLECULAR CYTOGENETICS USING ALPHA SATELLITE DNA PROBES

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
8029
Program Year/Program:
1988 / SBIR
Agency Tracking Number:
8029
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ONCOR, INC.
209 PERRY PARKWAY Gaithersburg, MD 20877
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1988
Title: MOLECULAR CYTOGENETICS USING ALPHA SATELLITE DNA PROBES
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

DIAGNOSIS OF NUMERICAL CHROMOSOME ABNORMALITIES IS ALMOST INVARIABLY BASED ON THE EVALUATION OF MITOTIC CHROMOSOME COMPLIMENTS USING CHROMOSOME BANDING TO FACILITATE INDIVIDUAL CHROMOSOME IDENTIFICATION. CHROMOSOME ANALYSIS HAS BECOME A MAJOR DIAGNOSTIC TOOL IN MANY AREAS OF MEDICINEINCLUDING OBSTETRICS, HEMATOLOGY, ONCOLOGY, AND CLINICAL GENETICS. DESPITE MAJOR ADVANCES IN THE FIELD OF CYTOGENETICS THE DIAGNOSIS OF CHROMOSOME ABNORMALITIES REMAINS A TIME-CONSUMING AND LABOR-INTENSIVE PROCEDURE PERFORMED BY HIGHLY TRAINED AND SKILLED TECHNOLOGISTS. THE OBJECTIVE OF THIS RESEARCH PROPOSAL IS TO TEST THE FEASABILITY OF DEVELOPING A RAPID DNA HYBRIDIZATION-BASED MOLECULAR CYTOGENETIC TEST FOR THE DIAGNOSIS OF CHROMOSOMAL SYNDROMES. THE TEST TO BE DEVELOPED IS BASED UPON HYBRIDIZATION IN SITU OF CHROMOSOME SPECIFIC REPETITIVE DNA PROBES TO DIVIDING OR NON-DIVIDING CELLS AND ON THE RAPID AND SENSITIVE DETECTION OF DIPLOIDY OR ANEUPLOIDY BY IMMUNOFLUORESCENCE OR HISTOCHEMICAL TECHNIQUES.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Oncor Inc
209 Perry Pky Suite 7 Gaithersburg, MD 20877

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No