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Telomeric DNA Probes for Clinical Diagnostics

Award Information

Agency:
Department of Health and Human Services 		Branch:
N/A 		Award ID:
19259 		Program Year/Program:
1995 / SBIR
Agency Tracking Number:
19259 		Solicitation Year:
N/A 		Solicitation Topic Code:
N/A 		Solicitation Number:
N/A
Small Business Information
ONCOR, INC.
209 PERRY PARKWAY Gaithersburg, MD 20877
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1995
Title: Telomeric DNA Probes for Clinical Diagnostics
Agency: HHS
Contract: N/A
Award Amount: $750,000.00
 

Abstract:

MOLECULAR CYTOGENETICS HAS HAD A MAJOR IMPACT ON CHROMOSOME ANALYSIS IN BOTH RESEARCH AND CLINICAL LABORATORIES. TELOMERES, TOGETHER WITH THE CENTROMERE, DEFINE THE PHYSICAL LIMITS OF EACH CHROMOSOME. CHROMOSOME-SPECIFIC CENTROMERE PROBES ARE PRESENTLY AVAILABLE. THESE PROBES, IN CONJUNCTION WITH CHROMOSOME-SPECIFIC TELOMERE PROBES, WOULD ALLOW DETECTION OF ALL MAJOR TRANSLOCATIONS INVOLVING A TELOMERE AS WELL AS SUBMICROSCOPIC TRANSLOCATIONS WHICH ARE STRONGLY INDICATED AS A FREQUENT CAUSE OF MENTAL RETARDATION, INFERTILITY AND MISCARRIAGE, AND SPECIFIC HUMAN CANCERS AND LEUKEMIAS. THE PHASE I EFFORT ADDRESSES THE FEASIBILITY OF DEVELOPING CHROMOSOME-SPECIFIC TELOMERIC PROBES UTILIZING A SOPHISTICATED STRATEGY OF SCREENING HUMAN GENOMIC LIBRARIES TO ISOLATE CLONES FOR BUILDING SETS OF OVERLAPPING COSMIDS (CONTIGS) TO USE AS MOLECULAR PROBES. TELOMERES ON THE SHORT ARMS OF CHROMOSOME 1 (1P),4(4P), AND 17(17P) ARE TARGETED FOR PHASE I. DEVELOPED PROBES WILL BE EVALUATED ON A VARIETY OF CLINICAL SAMPLES. MULTIPLE COLOR ANALYSIS FOR SIMULTANEOUS DETECTION OF MULTIPLE PROBES WILL BE INVESTIGATED. COMPLETION OF PHASE I WILL YIELD CLINICALLY-SIGNIFICANT IN SITU PROBES FOR HUMAN TELOMERES AND ESTABLISH A METHODOLOGY THAT WILL GREATLY ENHANCE ALL LEVELS OF MOLECULAR PROBE DEVELOPMENT.

Principal Investigator:

Jeanne Dietz-band
3019633500

Business Contact:

Small Business Information at Submission:

Oncor Inc.
209 Perry Parkway #7 Gaithersburg, MD 20877

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No