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MOLECULAR CYTOGENETIC ANALYSIS OF HUMAN CHROMOSOMES

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
19253
Program Year/Program:
1994 / SBIR
Agency Tracking Number:
19253
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ONCOR, INC.
209 PERRY PARKWAY Gaithersburg, MD 20877
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1994
Title: MOLECULAR CYTOGENETIC ANALYSIS OF HUMAN CHROMOSOMES
Agency: HHS
Contract: N/A
Award Amount: $702,400.00
 

Abstract:

CYTOGENETIC ANALYSIS IS AN IMPORTANT DIAGNOSTIC LABORATORY TOOL IN MEDICAL GENETICS, ONCOLOGY, AND GENETIC RESEARCH. NEARLY ONE IN EVERY 150 NEWBORNS IS AFFECTED WITH A CHROMOSOME DEFECT THAT REQUIRES ANALYSIS AND EVALUATION BY A CLINICAL CYTOGENETICS SERVICE. AN EQUIVALENT CASELOAD COMES FROM BOTH HEMATOLOGIC AND SOLID TUMORS THAT ARE EVALUATED CYTOGENETICALLY AS A ROUTINE PART OF CANCER DIAGNOSIS. HISTORICALLY, CYTOGENETIC ANALYSIS HAS BEEN PERFORMED BY SPECIALLY TRAINED TECHNOLOGISTS AND PROFESSIONALS WITH SPECIFIC EXPERTISE IN A VARIETY OF CHROMOSOME BANDING METHODS AND THEIR INTERPRETATION. HOWEVER, WITH THE INCREASING AWARENESS OF THE VALUE OF CYTOGENETIC ASSESSMENT IN BOTH CLINICAL MEDICINE AND IN RESEARCH, THERE IS BOTH A SHORTAGE OF QUALIFIED CYTOGENETICISTS AND AN INCREASED NEED FOR RAPID AND DEFINITIVE DIAGNOSTIC ASSAYS. THE CURRENT PHASE I EFFORT AIMS TO SIGNIFICANTLY IMPROVE THE EXISTING TECHNOLOGY BY: (1) EVALUATING RAPID METHODS OF GENERATING CHROMOSOME-SPECIFIC DNA PROBES FOR USE IN FLUORESCENCE IN SITU HYBRIDIZATION ASSAYS; AND (2) TESTING SEVERAL NEW APPROACHES TO PROBE LABELLING THAT WILL BOTH ENHANCE THE PERFORMANCE OF FLUORESCENCE ASSAYS BY ADDING ROUTINE DETECTION OF MULTIPLE CHROMOSOMES LABELLED WITH DIFFERENT COLORS AND SIGNIFICANTLY REDUCE THE TIME REQUIRED FOR DETECTION OF LABELLED PROBES.

Principal Investigator:

Jay George
3019633500

Business Contact:

Small Business Information at Submission:

Oncor Inc.
209 Perry Parkway Gaithersburg, MD 20877

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No