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CONTROL CELL LINES FOR USE IN MOLECULAR DIAGNOSTIC TESTS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
13641
Program Year/Program:
1990 / SBIR
Agency Tracking Number:
13641
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Oncore Analytics Inc
4900 Fannin Houston, TX 77004
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1990
Title: CONTROL CELL LINES FOR USE IN MOLECULAR DIAGNOSTIC TESTS
Agency: HHS
Contract: N/A
Award Amount: $23,750.00
 

Abstract:

THE SPECIFIC AIM IS TO DEVELOP HUMAN CELL LINES CONTAINING SPECIFIC, CLONED GENES OF THE PATHOGENIC VIRUS, HIV, THE CAUSATIVE AGENT OF AIDS. EACH CELL LINE WILL CONTAIN ONLY ONE INDIVIDUAL GENE OF HIV, EXPRESSED BY A EUKARYOTIC GENE PROMOTER. THESE CELL LINES WILL PROVIDE A NONINFECTIOUS, POSITIVE CONTROL STANDARD FOR SUCH DIAGNOSTIC MOLECULAR TESTS AS SOUTHERN ANALYSIS, NORTHERN ANALYSIS, IN SITU HYBRIDIZATION, AND THE POLYMERASE CHAIN REACTION. THE USE OF MOLECULAR BIOLOGY AS A DIAGNOSTIC TOOL IS GROWINGWORLDWIDE. AS THE INCLUSION OF A KNOWN POSITIVE CONTROL IS NECESSARY IN EVERY TEST, THESE NONINFECTIOUS CELL LINES WOULD ACT AS A STANDARD CONTROL. CURRENTLY, INFECTED MATERIALS FROM PATIENTS WITH AIDS ACT AS THESE CONTROLS. THESE MATERIALS ARE INFECTIOUS AND POSE A DIRECT HEALTH HAZARD TO THE LABORATORY WORKER. BY EMPLOYING THESE CONTROLCELL LINES, THAT RISK WOULD BE ELIMINATED. AIDS IS ONLY ONE OF MANY BLOOD-BORNE INFECTIOUS AGENTS. OTHER CONTROL CELL LINES, CONTAINING THE INDIVIDUAL GENES OFHTLV-I, HEPATITIS B, AND HUMAN PAPILLOMA VIRUS COULD ALSO BEDEVELOPED.

Principal Investigator:

C V Taylor Herst
7135236100

Business Contact:

Small Business Information at Submission:

Oncore Analytics Inc
4900 Fannin Houston, TX 77004

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No