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Company Information:

Name: OPERATIONAL TECHNOLOGIES CORPORATION
Address: 4100 N.W. LOOP 410
SAN ANTONIO, TX
Located in HUBZone: No
Woman-Owned: No
Minority-Owned: No
URL: N/A
Phone: (210) 731-0000

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $2,546,060.36 30
SBIR Phase II $2,836,935.00 5
STTR Phase I $99,969.00 1

Award List:

ROBOTICS MAINTENANCE TASK ASSESSMENT

Award Year / Program / Phase: 1988 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Douglas r brown
Award Amount: $49,990.00
Abstract:
The use of nuclear, biological, chemical (nbc) warfare against u.s. armed forces would drastically reduce the effectiveness of army aviation units by degrading vital maintenance capabilities. a reduction in this tremendously important military resource is unacceptable. the objective of this project… More

DEVELOPMENT OF A DECISION SUPPORT SYSTEM FOR HAZARDOUS MATERIALS IDENTIFICATION AND MANAGEMENT IN LARGE SCALE SYSTEMS

Award Year / Program / Phase: 1989 / SBIR / Phase I
Agency / Branch: DOD / USAF
Principal Investigator: Dr C B Harrah
Award Amount: $68,238.00

DEVELOPMENT OF A DECISION SUPPORT SYSTEM FOR HAZARDOUS MATERIALS IDENTIFICATION AND MANAGEMENT IN LARGE SCALE SYSTEMS

Award Year / Program / Phase: 1990 / SBIR / Phase II
Agency / Branch: DOD / USAF
Principal Investigator: Dr C B Harrah
Award Amount: $67,000.00
Abstract:
The identification and management of hazardous materials throughout the acquisition life cycle of large-scale systems are essential for the effective control of total life cycle costs. the explicit inclusion of health, safety and environmental factors, along with other supportability considerations,… More

Development of a Technology Transfer Work Station

Award Year / Program / Phase: 1993 / SBIR / Phase I
Agency / Branch: DOD / USAF
Principal Investigator: Cb Harrah
Award Amount: $89,710.00
Abstract:
The objective is to develop a computer-based technology transfer workstation to aid in the transfer of technology from federal laboratories to the private section. The technology transfer workstation will incorporate a decision support system (DSS) that will contain specific documents an data… More

Decision Support System for Research & Development Investment Strategy

Award Year / Program / Phase: 1993 / SBIR / Phase I
Agency / Branch: DOD / USAF
Principal Investigator: Cb Harrah
Award Amount: $87,752.00
Abstract:
The objective is to develop an expert system to serve as a decision aid to support resource allocation decision making in the Air Force Human Systems Center research and development community. This decision aid will incorporate the best methods for categorizing, prioritizing, and allocating… More

A Propensity Score Model of Costs and Benefits Related to Army Service

Award Year / Program / Phase: 1993 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: Benjamin A. Fairbank, Ph.
Award Amount: $49,997.00
Abstract:
A major obstacle to the establishment and measurement of valid cause and effect relationships between Army service and the costs and benefits of such service is the impossibility of performing experiments with random assignment of individuals to service and non-service groups. A recent innovation in… More

Development of a Workplace Risk Advisor for Human Engineering Design Review of System Maintenance

Award Year / Program / Phase: 1994 / SBIR / Phase I
Agency / Branch: DOD / USAF
Principal Investigator: C. B. Harrah
Award Amount: $59,973.00
Abstract:
OpTech proposes to develop a computer-based, integrated workplace risk assessment and workplace risk management decision support tool for use by design teams in evaluating candidate design configurations related to the maintenance functions of large-scale systems. Further, OpTech proposes to combine… More

Assessing Environmental Impacts on the LIfe Cycle of a System

Award Year / Program / Phase: 1997 / SBIR / Phase I
Agency / Branch: DOD / USAF
Principal Investigator: Dr. Peter A. Lurker, Pe,
Award Amount: $75,313.00
Abstract:
Operational Technologies Corporation teaming with Ball Aerospace Technolgoies Corporation proposes to develop an environmental life cycle impact cost (ELCIC) estimation tool for weapon system acquisition. The approach will be to begin with an update of the Cost Analysis Improvement Group's (CAIG's)… More

SBIR Phase I: Nuclease-Shielded DNA Aptamer 'Antibiotics' that Couple with Complement

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: NSF
Principal Investigator: John Bruno
Award Amount: $99,933.00
Abstract:
This Small Business Innovation Research (SBIR) Phase I project is to design DNA-aptamers that will be covalently linked to C1qrs and will subsequently induce an immune response to the target organism. Specifically, this Phase I work has the following key objectives: 1) recreating the aptamers… More

Magnetic Concentrator & Cartridge System to Enhance Food Safety

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency / Branch: DOD / CBD
Principal Investigator: John G. Bruno, Senior Scientist
Award Amount: $69,769.00
Abstract:
Foodborne pathogen detection has always been faced with volume and matrix problems, i.e., low numbers of viral or bacterial pathogens in a large volume of solid or liquid foods that are still potentially infectious. Despite sensitive techniques such as PCR and… More

Multiplexed-Magnetically Assisted Test Strips (M-MATS)

Award Year / Program / Phase: 2004 / STTR / Phase I
Agency / Branch: DOD / ARMY
Research Institution: Texas State University
Principal Investigator: John G. Bruno, Senior Scientist
Award Amount: $99,969.00
RI Contact: Billy C. Covington
Abstract:
Some biowarfare (BW) agents infect at extremely low doses and their detection is masked by debris-ridden water. Furthermore, a large variety of BW agents may be disbursed in a water supply, thus complicating detection. Therefore, ultrasensitive, multiplexed detection is required. To address this… More

Nuclease-Resistant Aptamers for Anthrax Opsonization

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: HHS
Principal Investigator: John G. Bruno
Award Amount: $99,934.00
Abstract:
DESCRIPTION (provided by investigator): The anti-phagocytic poly-D-glutamic acid (PDGA) capsule of Bacillus anthracis is a major virulence factor of inhalation anthrax. Although generation of antibodies to PDGA might be of value in opsonizing vegetative anthrax, such antibodies would require… More

FRET Aptamer-Based Biosensor Array for Homeland Defense

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: DHS
Principal Investigator: John G. Bruno, Senior Scientist
Award Amount: $99,692.00
Abstract:
Fluorescence Resonance Energy Transfer (FRET)-DNA aptamers are oligonucleotides that have been modified with fluorophores and quenchers in their structures so that upon binding to their target analytes, the fluorophore and quencher become separated and capable of emitting light to indicate that… More

Nuclease-Resistant Aptamers to Botox and Anthrax Toxins

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: HHS
Principal Investigator: John G. Bruno
Award Amount: $99,913.00
Abstract:
DESCRIPTION (provided by investigator): Botulinum toxin and anthrax are two likely bioweapons of choice in military attacks or terrorism against the United States. As such, effective post-exposure therapies, such as antitoxins, to both agents are required. Operational Technologies (OpTech) has… More

Fluorescent Nanoparticle-Aptmer-Magnetic Bead Sensor for Bioterrorism Detection in Water

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: EPA
Principal Investigator: John G. Bruno, Senior Scientist
Award Amount: $69,918.00
Abstract:
Some bioterrorism agents cause disease at very low infective doses and their presence can be masked by the environment. Therefore, ultrasensitive detection is required for homeland defense applications. In this Phase I research project, Operational Technologies Corporation (OpTech) proposes to… More

Fluorescent Aptamer Tests for Active and Latent Leishmania

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: John G. Bruno, Senior Scientist
Award Amount: $69,953.00
Abstract:
Operational Technologies Corporation (OpTech) proposes to couple the sensitivity of fluorescence-based assays with the high affinity and selectivity of DNA aptamers as replacements for antibodies to detect Leishmania infections. The primary target for detection of active cutaneous Leishmania… More

CW Agent FRET-Aptamer Spray & Compact Scanner

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency / Branch: DOD / DARPA
Principal Investigator: John G. Bruno, Senior Scientist
Award Amount: $98,994.00
Abstract:
Operational Technologies Corporation (OpTech) will develop and demonstrate a cocktail of several Fluorescence Resonance Energy Transfer (FRET)-DNA aptamer sequences of different analyte specificity in a single spray during Phase I for low-level detection of low-volatility chemical warfare (CW) agent… More

FRET-Aptamer Assays & Handheld Reader for Nerve Agent Metabolites

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency / Branch: DOD / CBD
Principal Investigator: John G. Bruno
Award Amount: $69,996.00
Abstract:
Operational Technologies Corporation (OpTech) proposes to couple the speed and ultrasensitivity of one-step ("bind and detect") fluorescence resonance energy transfer (FRET) detection with the high affinity and selectivity of DNA aptamers (surrogate antibodies) to detect the phosphonic acid… More

Handheld FRET-Aptamer Sensor for Agricultural Security

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: USDA
Principal Investigator: John G. Bruno, Senior Scientist
Award Amount: $79,986.00
Abstract:
America is highly vulnerable to agricultural bioterrorism. A successful attack could be devastating to the U.S. and world economy. Rapid detection of agricultural bioterrorism agents is critical to limiting or halting the spread of such disease agents. This project concerns development of a rapid,… More

Handheld FRET Aptamer Sensor to Satisy the Beaches Act

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: EPA
Principal Investigator: John G. Bruno, Senior Scientist
Award Amount: $69,993.00
Abstract:
Operational Technologies Corporation (OpTech) proposes to couple the ultrasensitivity of fluorescence-based detection with the high affinity and selectivity of DNA aptamers as improved replacements for antibodies to detect fecal indicator organisms in fresh and marine recreational waters. … More

Handheld FRET-Aptamer Sensor for Bone Markers

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: NASA
Principal Investigator: John G. Bruno, Principal Investigator
Award Amount: $99,948.00
Abstract:
Astronauts lose approximately 1-1.5% of their bone mass per month during space travel due to a lack of physical stress in the microgravity environment. Although, no effective treatments or prophylactic regimens have yet been defined, it is important to monitor the bone loss process in space. As… More

SBIR Phase I: FRET-Aptamer Tests for Treated Wastewater

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: NSF
Principal Investigator: John G. Bruno, PhD
Award Amount: $99,990.00
Abstract:
This Small Business Innovative Research (SBIR) Phase I project proposes to further develop its one-step fluorescence resonance energy transfer (FRET)-DNA aptamer technology for the rapid (assay results within minutes of sampling), sensitive, on-site detection of fecal bacteria in treated water… More

Handheld FRET-Aptamer Sensor for Bone Markers

Award Year / Program / Phase: 2009 / SBIR / Phase II
Agency: NASA
Principal Investigator: John G. Bruno, Principal Investigator
Award Amount: $599,983.00
Abstract:
Astronauts lose significant bone mass during lengthy spaceflights. Although, no effective treatments or prophylactics have yet been defined, it is important to monitor bone loss during missions. As such, the sensor must be compact and facile to operate in spacecraft. Operational Technologies Corp.… More

Handheld Aptamer-Magnetic Bead-Quantum Dot Assays for Crimean-Congo Fever

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: John G. Bruno, Senior Scientist
Award Amount: $69,967.00
Abstract:
Operational Technologies (OpTech) has already developed rapid (< 15 minute) ultrasensitive one-step DNA aptamer-magnetic bead (MB) plus aptamer-quantum dot (QD) sandwich assays for a foodborne pathogen that is quantified with a commercially available handheld and battery-operated fluorometer. … More

Combinatorial DNA Array Microsensor for Chem-Bio and Explosives

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency / Branch: DOD / USAF
Principal Investigator: John G. Bruno, Senior Analyst
Award Amount: $99,955.00
Abstract:
Operational Technologies Corporation proposes to further develop a novel Combinatorial DNA Array Recognition Surface (CARS) published by OpTechs senior scientist in IEEE Sensors Journal (7:1609-1616, 2007) for eventual universal sensing of any analyte including chem-bio and explosives in a handheld… More

Multiplex Aptamer-Based Sensor for Mosquito-borne Viruses

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency / Branch: DOD / OSD
Principal Investigator: John G. Bruno, Senior Scientist
Award Amount: $99,994.00
Abstract:
Operational Technologies Corporation (OpTech) has patents pending for: 1) one-step plastic-adherent aptamer-magnetic bead (MB) plus aptamer-quantum dot (QD) sandwich assays (that have already been successfully applied to ultrasensitive detection of Crimean-Congo Hemorrhagic Fever under a recent SBIR… More

Handheld FRET-Aptamer Sensor for Water Safety

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: NASA
Principal Investigator: John G. Bruno, Principal Investigator
Award Amount: $99,985.00
Abstract:
Operational Technologies Corporation (OpTech) proposes to expand its current NASA Phase 2 SBIR handheld fluorometer and bone marker fluorescence resonance energy transfer (FRET)-DNA aptamer assay system to include detection of bacteria, fungi, and parasites that may contaminate astronauts' water… More

Handheld Aptamer-Magnetic Bead-Quantum Dot Sensor for Leishmania

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency / Branch: DOD / OSD
Principal Investigator: John G. Bruno, Senior Scientist
Award Amount: $99,991.00
Abstract:
Operational Technologies (OpTech) has developed a rapid (15 minute) ultrasensitive one-step plastic-adherent DNA aptamer-magnetic bead (MB) plus aptamer-quantum dot (QD) sandwich assay for Campylobacter detection (J. Fluorescence 19:427-435, 2009) that is quantified with a commercially available… More

DNA APTAMERS FOR CARDIOVASCULAR RESEARCH

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: HHS
Principal Investigator: John Bruno
Award Amount: $99,991.00
Abstract:
Not Available

Multiplex Aptamer-Based Sensor for Tick-borne Diseases

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: John Bruno, Senior Scientist
Award Amount: $69,985.00
Abstract:
Operational Technologies Corporation (OpTech) has patents pending for: 1) one-step plastic-adherent aptamer-magnetic bead (MB) plus aptamer-quantum dot (QD) sandwich assays (already successfully applied to ultrasensitive detection of Crimean-Congo Hemorrhagic Fever or CCHF under a recent Army SBIR… More

Handheld Aptamer-Magnetic Bead-Quantum Dot Assays for Crimean-Congo Fever

Award Year / Program / Phase: 2010 / SBIR / Phase II
Agency / Branch: DOD / ARMY
Principal Investigator: John Bruno, Senior Scientist
Award Amount: $729,989.00
Abstract:
Operational Technologies Corporation (OpTech) has completed a successful Phase I proof-of-concept for a plastic-adherent DNA aptamer-magnetic bead (MB) plus aptamer-fluorescent nanoparticle assay for Crimean-Congo Hemorrhagic Fever (CCHF) virus in serum. By partitioning the assay away from the bulk… More

Handheld Aptamer-Magnetic Bead-Quantum Dot Sensor for Rickettsiae

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency / Branch: DOD / ARMY
Principal Investigator: John Bruno, Senior Scientist
Award Amount: $69,982.00
Abstract:
Operational Technologies (OpTech) has developed a rapid (15 minute) ultrasensitive one-step plastic-adherent DNA aptamer-magnetic bead (MB) plus aptamer-quantum dot (QD) sandwich assay for Campylobacter detection (J. Fluorescence 19:427-435, 2009), which is quantified with a commercially available… More

Handheld FRET-Aptamer Sensor for Chem-Bio Threats

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: EPA
Principal Investigator: John G. Bruno – (210) 731-0000
Award Amount: $79,984.36
Abstract:
"Operational Technology Corporation (OpTech) proposes to couple the ultrasensitivity of fluorescence-based detection with the high selectivity of synthetic DNA aptamers as replacements for antibodies to detect chemical and biological (CB) terrorism threats in 10 minutes or less from a variety of… More

Handheld Aptamer-Magnetic Bead-Quantum Dot Sensor for Leishmania

Award Year / Program / Phase: 2011 / SBIR / Phase II
Agency / Branch: DOD / DHP
Principal Investigator: John G. Bruno, Senior Scientist – (210) 731-0015
Award Amount: $709,977.00
Abstract:
Operational Technologies Corporation (OpTech) has completed a successful Phase I SBIR contract in which 72 new candidate DNA aptamer sequences against Leishmania major were developed and screened by ELISA-like plate assay. Several pilot assays were developed from the highest affinity candidate… More

Handheld Aptamer-Magnetic Bead-Quantum Dot Sensor for Rickettsiae

Award Year / Program / Phase: 2011 / SBIR / Phase II
Agency / Branch: DOD / ARMY
Principal Investigator: John Bruno, Senior Scientist – (210) 731-0000
Award Amount: $729,986.00
Abstract:
Operational Technologies Corporation (OpTech) has completed a successful Phase I SBIR contract in which 124 new candidate DNA aptamer sequences against five different species of rickettsiae were developed and screened by ELISA-like plate assay. Several pi

Development of Anti-OLAM Aptamers as Novel Analgesics

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: HHS
Principal Investigator: John G. Bruno – 210-731-0015
Award Amount: $147,234.00
Abstract:
DESCRIPTION (provided by applicant): Development of Anti-OLAM Aptamers as Novel Analgesics The management of pain remains a major health care problem due to an incomplete understanding of pain mechanisms. TRPV1, a prominent member of the transient receptorpotential (TRP) family of ligand-gated ion… More