VITRIFICATION FOR TISSUE ENGINEERED BLOOD VESSELS
DESCRIPTION (Verbatim From Applicant's Abstract): Effective methods of
preservation are irnportant for the remerging technology of tissue engineering.
We recently demonstrated, for the first time, that vitrification can have a
salutary effect on the cryopreservation of a complete tissue, rabbit jugular
vein, which otherwise sustains significant injury from freezing. Restriction of
the amount and size of ice crystal formation during cryopreservation can be
achieved by promotion of amorphous solidification (vitrification) rather than
crystallization In this Phase I SBIR proposal, the primary objective is to test
the feasibility of employing vitrification for long-term storage of tissue
engineered blood vessels (TEBV). The effects of vitrification and conventional
cryopreservation involving ice formation will be assessed using biomechanical
tests, cell viability assays and vascular physiology methods. If vitrification
is shown to be feasible for storage of TEBVs, these studies will be extended to
a Phase II SBIR proposal to include in vivo testing of the Duke University
TEBVs and TEBVs being developed by other organizations.
PROPOSED COMMERCIAL APPLICATION:
Customers are tissue engineering, tissue processing and banking organizations, and
companies supplying reagents and biological materials to research organizations. The
tissue engineering industry addresses diseases and disorders associated with over
$500 billion expended annually in the U.S. for health care costs.
Small Business Information at Submission:
Principal Investigator:Ying C. Song
ORGAN RECOVERY SYSTEMS, INC.
2570 E DEVON AVE DES PLAINES, IL 60018
Number of Employees: