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Company Information:

Company Name:
ORIGINUS, INC.
Address:
3970 VARSITY DRIVE
ANN ARBOR, MI
Phone:
N/A
URL:
N/A
EIN:
383576863
DUNS:
100651889
Number of Employees:
N/A
Woman-Owned?:
No
Minority-Owned?:
No
HUBZone-Owned?:
No

Commercialization:

Has been acquired/merged with?:
N/A
Has had Spin-off?:
N/A
Has Had IPO?:
N/A
Year of IPO:
N/A
Has Patents?:
N/A
Number of Patents:
N/A
Total Sales to Date $:
$ 0.00
Total Investment to Date $
$ 0.00
POC Title:
N/A
POC Name:
N/A
POC Phone:
N/A
POC Email:
N/A
Narrative:
N/A

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $1,509,102.00 4
SBIR Phase II $2,213,765.00 2

Award List:

Screening Method for GPCRs Related to Appetite

Award Year / Program / Phase:
2004 / SBIR / Phase I
Award Amount:
$99,617.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant): The long-term goal of this project is to develop tools for high throughput testing of drug compounds from combinatorial libraries that target G-Protein-Coupled Receptors (GPCR's) associated with appetite control and eating behavior. The development of drugs aimed… More

Screening Method for GPCRs Related to Appetite

Award Year / Program / Phase:
2005 / SBIR / Phase II
Award Amount:
$1,343,272.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant): The development of drugs aimed at reducing obesity and controlling eating disorders represents a major target of the pharmaceutical industry and has become one of the most exciting areas in drug discovery. The long term goal of this project is to develop tools… More

DEVELOPMENT OF HIGH DENSITY DRUG SCREENING OF NEURAL GPCR's USING STEP ARRAYS

Award Year / Program / Phase:
2008 / SBIR / Phase I
Award Amount:
$492,783.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant): Recent advances in genomics and proteomics have produced rapid changes in drug discovery, increasing the speed of the High Throughput Screening (HTS) methods by using simple assays on isolated protein targets but sacrif icing depth of information and making… More

RAPID NEURAL DIFFERENTIATION OF HUMAN STEM CELLS: A NOVEL DRUG DISCOVERY PLATFORM

Award Year / Program / Phase:
2009 / SBIR / Phase I
Award Amount:
$694,281.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant): A current major challenge in pharmaceutical industry is to develop treatments for brain diseases and mental disorders such as depression, anxiety, schizophrenia, epilepsy, addiction and many more. Over the last decade, the drug discovery process has evolved… More

NOVEL HIGH THROUGHPUT PLATFORM FOR SCREENING CYTOCHROME P450 INDUCTION

Award Year / Program / Phase:
2011 / SBIR / Phase I
Award Amount:
$222,421.00
Agency:
HHS
Principal Investigator:
Maria I. Morano – 734-913-8791
Abstract:
DESCRIPTION (provided by applicant): Metabolism of administered drugs is determined by expression and activity of drug-metabolizing enzymes, such as cytochrome (CYP) P450 enzymes. These P450s are subject to inhibition and sometimes induction by xenobiotics, leading to possible pharmacokinetic… More

NOVEL HIGH THROUGHPUT PLATFORM FOR SCREENING CYTOCHROME P450 INDUCTION

Award Year / Program / Phase:
2012 / SBIR / Phase II
Award Amount:
$870,493.00
Agency:
HHS
Principal Investigator:
Maria I. Morano – 734-913-8791
Abstract:
DESCRIPTION (provided by applicant): Many prescribed drugs exhibit drug-drug interactions due to up-regulation or inhibition of specific P450 enzymes. According to a recent guidance from the FDA, CYP1A2, CYP2B6, and CYP3A4 induction should be evaluated inat least an in vitro system. Enzymatic… More