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Develop Assay for 9,11 3-Hydroxyoctadecadienoic Acid

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
25055
Program Year/Program:
1994 / SBIR
Agency Tracking Number:
25055
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
OXFORD BIOMEDICAL RESEARCH, INC.
2165 AVON INDUSTRIAL DRIVE ROCHESTER HILLS, MI 48309-
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1994
Title: Develop Assay for 9,11 3-Hydroxyoctadecadienoic Acid
Agency: HHS
Contract: 1 N43 ES41001-00,
Award Amount: $75,000.00
 

Abstract:

Linoleic acid, the predominant polyunsaturated fatty acid (PUFA) in the human diet, can bemetabolized by cyclooxgenase, lipoxygenase and P450 enzymes. The monohydroxy derivatives oflinoleic acid, 9(S)-HODE and 13 (S)-HODE, are the most widely distributed of the known linoleic acidmetabolites. These compounds exhibit interesting biologic activities, including regulation of plateletfunction, maintenance of vascular thromboresistance and transduction of the cellular responses tocertain growth factors. The HODE derivatives of linoleic acid may also influence certain pathologicalstates including, psoriasis, the development of atherosclerosis and the development of cancer. Indeed,there is a strong positive correlation between the polyunsaturated fatty acid (PUFA) content of thehuman diet and the incidence of colorectal and breast cancers. Further studies on the physiologic andpathophysiologic roles of HODEs has been slowed by the lack of simple and convenient assays specificfor these compounds. Therefore, the ultimate goal of the present proposal is the development ofsensitive and specific immunoassays for these linoleic acid metabolites. Based on evidence obtained todate, it is also possible that the immunoassay reagents developed during the proposed studies will haveimportant diagnostic application in certain diseases, including atherosclerosis and cancer.

Principal Investigator:

Ramesh Reddy
8106285104

Business Contact:

Small Business Information at Submission:

Oxford Biomedical Research,
Box 522, 1600 Hosner Road Oxford, MI 48371

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No