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BIOMARKER FOR SUBARACHNOID HEMORRHAGE

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
61140
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
NS040175
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
P2D, INC.
10101 Alliance Rd CINCINNATI, OH 45242-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: BIOMARKER FOR SUBARACHNOID HEMORRHAGE
Agency: HHS
Contract: 1R43NS040175-01A2
Award Amount: $128,125.00
 

Abstract:

DESCRIPTION (provided by applicant): The objective of this Phase I application is to develop a new quantitative clinical biomarker for subarachnoid hemorrhage (SAH). Acute headache is initially screened for SAH by computed tomography (CT). CT-negative patients suspected of SAH are then screened for cerebrspinal fluid (CSF) xanthochromia, which has documented limitations and is not FDA-approved. The present application proposes to develop a new biomarker, cleaved MAP-tau (C-tau). The proposed biomarker should demonstrate increased sensitivity and specificity, as well as, improving point of care treatment by using immunocard technology. We have developed a sandwich ELISA that specifically quantifies this neuronally localized protein, C-tau, that is released from damaged neurons. Employing our C-tau ELISA, we demonstrate in preliminary studies that CSF C-tau levels are elevated 1 ,000 fold in SAH patients compared to neurologic controls. Our Specific Aims are: Specific Aim 1: Determine if CSF C-tau levels are significantly elevated in CT-negative acute headache patients with SAH compared patients without SAH determined at three month follow up (N=150). Specific Aim 2: Determine if differences in CSF C-tau level between SAH(+) and SAH(-) patients are time dependent (Specific Aim 1).

Principal Investigator:

Frank P. Zemlan
5134756618
FZEMLAN@PHASE2D.COM

Business Contact:

James Hillard
5135584274
Small Business Information at Submission:

PHASE 2 DISCOVERY, INC.
PHASE 2 DISCOVERY, INC. 3130 HIGHLAND AVE, 3RD FL CINCINNATI, OH 45219

EIN/Tax ID: 311760570
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No