USA flag logo/image

An Official Website of the United States Government

Selective DAT Inhibitor for Treatment of ADHD

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
85886
Program Year/Program:
2007 / SBIR
Agency Tracking Number:
MH081381
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
P2D, INC.
10101 Alliance Rd CINCINNATI, OH 45242-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2007
Title: Selective DAT Inhibitor for Treatment of ADHD
Agency: HHS
Contract: 1R43MH081381-01
Award Amount: $228,706.00
 

Abstract:

DESCRIPTION (provided by applicant): Currently, the non-selective dopamine (DA) transport inhibitors methylphenidate and d- amphetamine are the only approved first line treatments for Attention Deficit/Hyperactivity Disorder (ADHD). As both drugs are Sched ule II drugs of abuse primarily administered to children, a priority at the National Institute on Drug Abuse and the National Institute of Mental Health is to developed a safe and effective alternative to these drugs that has little or no abuse potential. The goal of the present studies is to assess whether our lead compound, PD2005, meets these criteria. Extensive research suggests that the mechanism of action of both drugs in treating ADHD is inhibition of the DA transporter. PD2005 is a selective DA tran sport inhibitor. It is an analog of benztropine, a FDA-approved selective DA transport inhibitor in clinical use for over 30 years. Unfortunately, benztropine is a potent anticholinergic that precluded it use as an ADHD treatment. Extensive lead optimizati on studies have identified the benztropine analog, PD2005, as a selective DA transport inhibitor with no anticholinergic properties. Further, PD2005 is a psychostimulant that demonstrates no abuse potential in preclinical studies (e.g. does not support sel f- administration in monkeys). The proposed studies will assess the efficacy of PD2005 in well established preclinical ADHD screening models, our Specific Aims are: Specific Aim 1: Assess the effect of PD2005 on locomotor activity in an ADHD rodent model o f hyperactivity and on the circadian pattern of locomotor activity. Specific Aim 2: Assess the effect of PD2005 on executive cognitive function employing two preclinical ADHD rodent models of: a) working memory, and b) sustained attention. In the present a pplication, we propose preclinical studies to assess whether our proprietary compound, PD2005 - a selective inhibitor of the dopamine transporter, is an effective treatment for Attention-Deficit/Hyperactivity Disorder (ADHD). These preclinical studies will assess three main symptoms of ADHD observed in humans, hyperactivity, working memory and sustained attention. The effect of PD2005 on all three of these dimensions of ADHD will be determined in the proposed studies. Additionally, the effect of a positive control, methylphenidate - a FDA-approved treatment for ADHD in humans, will be assessed in all studies

Principal Investigator:

Frank Zemlan
5134756618
FZEMLAN@P2DINC.COM

Business Contact:

Renee O'connor
rmooconnor@p2dinc.com
Small Business Information at Submission:

P2D, INC.
P2D, INC. 3130 HIGHLAND AVE, 3RD FL CINCINNATI, OH 45219

EIN/Tax ID: 202224724
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No