USA flag logo/image

An Official Website of the United States Government

Three-Dimensional Matrices for Cellular and Multicellular Biointerfaces

Award Information

Agency:
Department of Defense
Branch:
Defense Advanced Research Projects Agency
Award ID:
40425
Program Year/Program:
1998 / SBIR
Agency Tracking Number:
40425
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Pacific-sierra Research Corp.
2901 28th St Suite 300 Santa Monica, CA 90405
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1998
Title: Three-Dimensional Matrices for Cellular and Multicellular Biointerfaces
Agency / Branch: DOD / DARPA
Contract: N/A
Award Amount: $98,981.00
 

Abstract:

Biological macromolecules are highly efficient at recognizing specific analytes or catalyzing reactions in aqueous biological media; however, their natural liquid environment limits military practicality. Any delineation from the preferred buffered aqueous environment results in partial or total loss of reactivity. It would be advantageous to immobilize biological macromolecules in alternative environments that stabilize them and preserve their reactivities. The proposed effort introduces a revolutionary matrix called aerogel to immobilize cells resulting in a biologically active solid matrix. Sof-gel chemistry will be utilized to immobilize the cells in the silica matrix. The silica matrix has an extremely large internal surface area, low density, high porosity, and adjustable pore size, which together render a highly efficient, lightweight matrix for cell immobilization. Also, the silica matrix provides a protective environment for cells, thus increasing shelf life and reactivity.

Principal Investigator:

Charles Daitch
8049233673

Business Contact:


0
Small Business Information at Submission:

PACIFIC-SIERRA RESEARCH CORP.
1400 Key Boulevard, Suite 700 Arlington, VA 22209

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No