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STTR PHASE I: PLANAR ARRAY INFRARED(PA-IR): A COMPACT RUGGED DOUBLE BEAM…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
94082
Program Year/Program:
2009 / STTR
Agency Tracking Number:
RR024768
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
PAIR Technologies, LLC
P.O. Box 7167 Wilmington, DE 19803-0167
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2009
Title: STTR PHASE I: PLANAR ARRAY INFRARED(PA-IR): A COMPACT RUGGED DOUBLE BEAM INFRARED
Agency: HHS
Contract: 1R41RR024768-01A1
Award Amount: $131,868.00
 

Abstract:

DESCRIPTION (provided by applicant): There are currently a significant number of research programs directed at the utilization of vibrational spectroscopy (infrared, near infrared and Raman) as diagnostic tools for a variety of diseases. Almost all of thes e efforts utilize existing, commercially available instrumentation which for infrared measurements rely almost entirely on Fourier transform infrared (FT-IR) interferometers. In order for the results from these existing programs to effectively translate fr om the laboratory to the bed-side (translational research), there needs to be a new generation of infrared and near infrared instrumentation, that is 1) laboratory quality for both routine and nonstandard measurements, and 2) portable, field deployable, an d responsive to a wide variety of substances (proteins, metabolites, and blood components). Such infrared instrumentation must be able to rapidly produce high quality spectra in the laboratory while possessing the requisite sensitivity and inherent stabili ty to do low level analysis of biologically relevant species outside of a laboratory under ambient conditions. We propose to design and construct a new type of portable, ultra-rapid infrared instrument based on focal plane array detection. This planar arra y IR (PA-IR) instrument will provide the time- resolution (10-15 ms) to follow real-time irreversible processes and provide information on a timescale which is not readily accessible to current FT-IR instruments. The instrument will also be capable of pe rforming real-time background corrections thus providing for compensation of water vapor in the atmosphere, for liquid water in the case of proteins in aqueous solutions (this application) or for real time subtraction of solvent bands. This can be a critic al issue when the infrared or near infrared measurements are translated to the clinic or bedside. Our longer range effort will be to extend this technology to create a small portable PA-IR spectrometer with the following improvements. The dual beam system will be a marked improvement over all present FT-IR systems as they do not have simultaneous reference and sample capability. The PA-IR system will also be capable of multiple simultaneous spectral acquisitions. In addition, the use of thermoelectric cooli ng systems will be investigated to eliminate the need for liquid nitrogen cooling of the detector system. If these technical goals are obtained our future plans would include prototyping, manufacturing and sales of these instruments. It is our long term go al to provide this system to academia, government and industry. If successful, we will provide improved capability with respect to the present generation of research grade FT-IR instruments (acquisition rate and dual beam capability) at a comparable cost. PUBLIC HEALTH RELEVANCE: There is a very strong interest in the public health community to drive diagnostic methods from the laboratory to the clinic or office, bench to bedside . An integral component of this transition is the development of small, compa ct, rugged and reliable analytical instrumentation. The increasing level of research results showing the relevance of vibrational spectroscopy to disease diagnosis accentuates the need for the spectroscopic instrumentation embodied in this program.

Principal Investigator:

Daniel W. Frost
3026954434
DWF62@COMCAST.NET

Business Contact:

Dan Frost
chase@pairtech.com
Small Business Information at Submission:

PAIR TECHNOLOGIES, LLC
PAIR TECHNOLOGIES, LLC 1 Innovation Way Newark, DE 19711

EIN/Tax ID: 421675505
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
UNIVERSITY OF DELAWARE
UNIVERSITY OF DELAWARE
Research Office
NEWARK, DE 19716-3098
RI Type: Nonprofit college or university