DESCRIPTION (provided by applicant): Anthrax Lethal Factor (LF) is a metalloproteinase introduced into the cells of mammalian hosts during infection by the bacterium Bacillus anthracis. LF disrupts intracellular signaling pathways mediated by the MAPKKs, r
esulting in cell toxicity, sepsis,… More
DESCRIPTION (provided by applicant): Ebola and Marburg viruses, the only members of the family Filoviridae, cause hemorrhagic fevers which are lethal in up to 90% of human cases. No vaccine or antiviral therapy currently exists to prevent or treat Filoviru
s infection. Due to their exceptional… More
Award Year / Program / Phase:2008 / SBIR / Phase I
Agency:HHS
Principal Investigator:
Award Amount:$599,957.00
Abstract:
DESCRIPTION (provided by applicant): Over half of the world population is at risk for infection by dengue virus, a mosquito borne member of the Flavivirus family that consists of four distinct serotypes. Approximately 50 to 100 million infections occur ann
ually resulting in an estimated 500,000… More