This Small Business Innovation Research Phase I project will develop micromachined fluid handling components as part of a new technology platform for high throughput protein crystallization and the collection of single crystal x-ray diffraction data. As increasing effort is directed toward… More

The use of DNA arrays for numerous applications has expanded rapidly in recent years. These arrays are made primarily using photolabile ligands as blocking groups in an array format or by spotting DNA from organisms or a DNA synthesizer. We propose an on-chip, high-density DNA oligomer growth method… More

This Small Business Innovation Research Project proposes to use silicon microfabrication techniques to produce new silicon spotting pins that will be used for the preparation of microarrays. Microarray technology has rapidly spread into many diverse areas of biological research. The preparation of a… More

This Small Business Innovation Research (SBIR) Phase I project proposes to develop a new type of nanoengineered surface to epitaxially nucleate protein crystals. These surfaces should greatly accelerate most high throughput Structural Genomics efforts. The basic concept for the epitaxial surfaces… More

This Small Business Innovation Research (SBIR) Phase II project proposes to develop a new, commercially viable micromachined silicon technology platform for the printing of DNA microarrays that offer significant advantages over current steel pin technology in cost and in quality. The Phase I effort… More

This Small Business Innovation Research (SBIR) Phase II project proposes to develop a new, commercially viable micromachined silicon technology platform for the printing of DNA microarrays that offer significant advantages over current steel pin technology in cost and in quality. The Phase I effort… More

DESCRIPTION (provided by applicant): If higher quality DNA microarrays could be fabricated at a much faster rate and at significantly lower cost, then new applications such as the measurement of real time gene expression might become feasible. Many microarrays are currently printed with steel pins… More

DESCRIPTION (provided by applicant): A new optical encoding method for labeling large numbers of samples based on measurement of emission ratios in samples containing various ratios of rare earth infrared upconverting phosphor (RUP) labels is described. Preliminary data suggest it may be possible to… More

DESCRIPTION (provided by applicant): During the Phase I effort, a totally new type of passive microcontact printing tool was developed by Parallel Synthesis Technologies that can print microarrays of a quality, cost and speed previously unobtainable. Silicon micromachining techniques were employed… More

This Small Business Innovation Research Phase I Project proposes to develop a disposable polymer based microarray printing device that will cost a small fraction of the current state of the art devices and at the same time offer significant improvements in reliability and performance. In spite of… More

DESCRIPTION (provided by applicant): Chip based assays such as DNA or protein microarrays, where each sample is identified by its x, y coordinate on the substrate, currently possess the highest sample density (samples/area) of any format. It seems possible that particle based assays could provide… More

DESCRIPTION (provided by applicant): The large number of different techniques employed to thwart counterfeiting and tampering of pharmaceuticals, and large amount of money invested in this area, reflects both the pervasive nature of the problem and the lack of a secure and robust means of… More

This Small Business Innovation Research (SBIR) Phase I project proposes to develop a taggant and anticounterfeiting/object authentication system based on a totally new type of optically encoded nanoparticle which can uniquely label almost any physical object and distinguish it from millions of other… More

DESCRIPTION (provided by applicant): The central hypothesis of the Phase I effort was that if a material could be synthesized that could emit millions of unique, resolvable optical signatures, and biomolecules such as DNA could be firmly attached to them, that this deeply multiplexed bead set could… More

This Small Business Innovation Research (SBIR) Phase II project will provide a system that is capable of easily labeling documents, with millions of unique optical signatures that provide a means of distinguishing these documents from other similar objects. Since there are no suitable commercial… More

DESCRIPTION (provided by applicant): The lack of rapid, inexpensive and accurate fluid transfer technology for volumes below one microliter is becoming a limiting factor in attempts to increase the sample density and assay accuracy of many high throughput processes. High throughput experiments such… More

DESCRIPTION (provided by applicant): The counterfeiting of consumer goods, documents and other valuable objects has always been a perpetual and widespread problem for humankind. Perhaps the most costly and morally reprehensible form of counterfeiting is th e manufacture of counterfeit pharmaceutical… More

This Small Business Innovation Research (SBIR) Phase II project provides an inexpensive disposable polymer tool that will perform extremely accurate fluid transfer in the picoliter to nanoliter range. Research efforts have already demonstrated that the costs associated with fabricating molds… More

This Small Business Innovation Research (SBIR) Phase I research project aims to develop a new platform for performing multiple DNA hybridizations that uses optically encoded beads attached to a probe that is homologous to a region of the target and a labeled reporter molecule that is homologous to… More

DESCRIPTION (provided by applicant): The Polymerase Chain Reaction (PCR) is one of the most useful and generally applicable protocols in molecular biology and forms the basis of an increasing number of diagnostic tests and other assays. It would be highly desirable to be able to screen a single… More

DESCRIPTION (provided by applicant): The last decade has witnessed substantial improvement in the development of parallel screening technologies designed to detect many types of biological threats. One type of screening technology has concentrated on mitig ating threats caused by viral Biothreat… More

DESCRIPTION (provided by applicant): The projected demands for safe, rapid and reliable technology for the storage and retrieval of genetic materials in medical, forensic and research applications are being addressed with increasing difficulty by many of t he current technologies. We propose a new… More

This award is funded under the American Recovery and Reinvestment Act of 2009 Public Law 111-5). This SBIR Phase II project will provide technology to perform remote nucleic acid testing (NAT) in any location. The combination of (a) our Probe-Target-Reporter (PTR) assay which allows the detection… More

DESCRIPTION (provided by applicant): Multiplexing technologies have steadily gained in popularity in the fields of biology and biochemistry as the desire to perform higher-throughput and lower-cost reactions has increased. Optical multiplexing consists of attaching a known biological probe to a… More

DESCRIPTION (provided by applicant): The accurate and rapid transfer of fluids is an integral part of nearly every biochemical reaction, assay or diagnostic test. While fluid transfer technology using disposable polymer pipette tips is well developed for v olumes above one microliter, manipulating… More

DESCRIPTION (provided by applicant): High Throughput Microrepository for Genetic Materials Recognizing the urgent need for a safe, rapid and reliable means of preserving and archiving genetic samples and other biological materials, such as synthetic DNA samples, unique isolated samples, plasmids,… More