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IN CARDIOVASCULAR RESEARCH THERE IS AN URGENT NEED FOR METHODS WHICH WOULD…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
3230
Program Year/Program:
1985 / SBIR
Agency Tracking Number:
3230
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Creare Inc.
P.O. Box 71 Hanover, NH 03755-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1985
Title: IN CARDIOVASCULAR RESEARCH THERE IS AN URGENT NEED FOR METHODS WHICH WOULD QUANTITATIVELY IDENTIFY REGIONS OF HIGH SHEAR STRESSES IN THE FLOW (HEMOLYTIC FACTOR), REGIONS OF HIGH AND LOW STRESSES AT THE WALL (ATHEROMATIC LESIONS), AND SEPARATED OR REVERSE
Agency: HHS
Contract: N/A
Award Amount: $42,000.00
 

Abstract:

IN CARDIOVASCULAR RESEARCH THERE IS AN URGENT NEED FOR METHODS WHICH WOULD QUANTITATIVELY IDENTIFY REGIONS OF HIGH SHEAR STRESSES IN THE FLOW (HEMOLYTIC FACTOR), REGIONS OF HIGH AND LOW STRESSES AT THE WALL (ATHEROMATIC LESIONS), AND SEPARATED OR REVERSE FLOW REGIONS (THROMBOGENIC FACTORS). A COMPUTER MODEL CAPABLE OF SIMULATING PHYSIOLOGICALLY IMPORTANT FEATURES OF BLOOD FLOW IN VESSELS WOULD BE AN INDISPENSABLE RESEARCH TOOL. THE OBJECTIVE OF THIS PROPOSAL IS TO DEVELOP SUCH COMPUTER SOFTWARE. THE COMPUTER MODEL WILL BE ABLE TO CALCULATE THREE-DIMENSIONAL TIME-DEPENDENT FLOW FOR AN ARBITRARY VESSEL GEOMETRY, INCLUDING LESIONS AND BIFURCATIONS, AND A WIDE RANGE OF REYNOLDS NUMBERS. BASED ON PREVIOUS WORK, OUR APPROACH WILL INVOLVE DISCRETIZING INTEGRAL MOMENTUM AND MASS BALANCE EQUATIONS IN PRIMITIVE VARIABLES ON A STAGGERED, NUMERICALLY GENERATED BOUNDARY-CONFORMING GRID. IMPLICIT FORMULATION WILL PROVIDE THE NUMERICAL STABILITY NEEDED TO RESOLVE THIN BOUNDARY LAYERS. A SPECIAL APPROXIMATION FOR CONVECTIVE TERMS WILL ELIMINATE NUMERICAL DIFFUSION. THE EXPECTED RESULTS OF PHASE I ARE THE DESIGN OF A TWO-DIMENSIONAL VERSION OF THE PROGRAM AND NUMERICAL EXPERIMENTATION TO ASSESS CODE UTILITY WITH RESPECT TO STATED OBJECTIVE. THE FINAL THREE-DIMENSIONAL VERSION OF THE CODE WILL BE DEVELOPED IN PHASE II.

Principal Investigator:

Arkady s. dvinsky
PRINCIPAL INVESTIGATOR
6036433800

Business Contact:

Small Business Information at Submission:

Creare Inc
P.o. Box 71 Hanover, NH 03755

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No