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NOVEL ANTIHYPERTENSIVE PEPTIDE

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
11330
Program Year/Program:
1989 / SBIR
Agency Tracking Number:
11330
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Peptech Inc
1 Progress Boulevard Box 26 Alachua, FL 32615
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Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1989
Title: NOVEL ANTIHYPERTENSIVE PEPTIDE
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE PHASE I OBJECTIVE IS TO DETERMINE IF A NOVEL PEPTIDE THAT HAS BEEN SHOWN TO BIND TO AND CONVERT ARGININE VASOPRESSIN (AVP) INTO AN ANTAGONIST OF ITS POSITIVE SIGNAL FOR LYMPHOKINE PRODUCTION CAN ALSO CONVERT AVP INTO AN ANTAGONIST OF ITS VASOPRESSOR AND ANTIDIURETIC PROPERTIES. PEPTECH, INC., WILL ACHIEVE THIS OBJECTIVE BY DETERMINING IFTHE AVP-BINDING PEPTIDE CAN BLOCK: (1) THE AVP VASOPRESSOR PROPERTY OF STIMULATING PHOSPHOLIPID TURNOVER IN MURINE HEPATOCYTES, AND (2) THE AVP ANTIDIURETIC PROPERTY OF STIMULATING ACTIVATION OF ADENYLATE CYCLASE IN MURINE KIDNEYCELLS AND INCREASING THE LEVEL OF THE SECOND-MESSENGER CYCLIC AMP. IF THE AVP-BINDING PEPTIDE CAN BLOCK THE VASOPRESSOR AND ANTIDIURETIC PROPERTIES OF AVP, THEN IT WOULD BE OF CONSIDERABLE IMPORTANCE AS A DIURETIC FOR CONTROLLING HYPERTENSION AND BLOOD VESSEL CONTRACTION. THISHAS POTENTIAL FOR THE TREATMENT OF HYPERTENSION IN CARDIOVASCULAR AND METABOLIC DISORDERS. THIS APPROACH DIFFERS SIGNIFICANTLY FROM THAT OF PREVIOUS STUDIES OF AVP ANTAGONISTS IN THAT THOSE STUDIES INVOLVED COMPETITION FOR THE AVP ANTIDIURETIC AND VASOPRESSOR RECEPTORS, WHILE THIS PEPTIDE BLOCKS AVP FUNCTION BY BINDINGTO THE HORMONE ITSELF AND CONVERTING IT INTO AN ANTAGONIST OF ITS OWN ACTION.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Peptech Inc
Box 26 1 Progress Blvd Alachua, FL 32615

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No