The syntheses of 23 cholecystokinin-octapeptide analogues and peptide antagonists are proposed. the preparation of these peptides will involve solid-phase techniques and purification on a new instrument for countercurrent chromatography, the horizontal flow-through coil planet centriguge. the… More

The syntheses of 19 cholecystokinin-octapeptide analogues are proposed. the preparation of these peptides will involve solid-phase techniques and purification of a new instrument for counter-current chromatography, the horizontal flow-through coil planet centrifuge. the binding of these peptides to… More

Bombesin is a gastrointestinal hormone and a neurally activepeptide that stimulates gastric acid secretion via gastrin release. the peptide is behaviorally active in suppressing food intake and lowering body temperature. the mammalian endogenous form of the peptide is ectopically produced in small… More

The antibiotic viscosin, a cyclic depsipeptide isolated frompseudomonas viscosa, shows promising in vitro and in vivo (mice) cytotoxicity against trypanosoma cruzi, the causativeagent in chagas" disease. the total synthesis of viscosin is proposed in order to confirm its chemical structure and and… More

A new countercurrent chromatography instrument, the cross-axis, flow-through coil planet cetrifuge, which is equipped with eccentrically oriented multilayer coils, is proposed for the preparative chromatography of peptides. this is an apparatus that separates substances according to their… More

Endothelin is a potent vasoactive peptide, recently discovered as the formerly described endothelial cell-derived contracting factor involved in the regulation of vascular tone. although endothelin possesses potent vasoconstrictor activity in vitro, its actions in vivo appear to be complex. in the… More

Possible therapeutics for neuroendocrine and gastrointestinal tumors and neuropsychiatric diseases may be developed from peptide antagonists of the central nervoussystem cholecystokinin receptor. structurally modified cholecystokinin octapeptide fragments will be tested for interaction with… More

Recent bombesin and gastrin releasing peptide receptor antagonists have been demonstrated to b e quite potent in inhibiting the effects of bombesin in pancreatic acinar cells, brain membranes, swiss 3t3 fibroblasts, and human small cell lung carcinoma (sclc). however, these antagonists do not… More