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THE SYNTHESES OF 23 CHOLECYSTOKININ-OCTAPEPTIDE ANALOGUES AND PEPTIDE…

Award Information

Agency:
National Science Foundation
Branch:
N/A
Award ID:
1798
Program Year/Program:
1984 / SBIR
Agency Tracking Number:
1798
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Peptide Technolgies Corp.
PO BOX 368 MAIN 125 MICHIGAN AVE NE Washington, DC 20017
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Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1984
Title: THE SYNTHESES OF 23 CHOLECYSTOKININ-OCTAPEPTIDE ANALOGUES AND PEPTIDE ANTAGONISTS ARE PROPOSED.
Agency: NSF
Contract: N/A
Award Amount: $35,000.00
 

Abstract:

THE SYNTHESES OF 23 CHOLECYSTOKININ-OCTAPEPTIDE ANALOGUES AND PEPTIDE ANTAGONISTS ARE PROPOSED. THE PREPARATION OF THESE PEPTIDES WILL INVOLVE SOLID-PHASE TECHNIQUES AND PURIFICATION ON A NEW INSTRUMENT FOR COUNTERCURRENT CHROMATOGRAPHY, THE HORIZONTAL FLOW-THROUGH COIL PLANET CENTRIGUGE. THE BINDING OF THESE PEPTIDES TO CHOLECYSTOKININCENTRAL NERVOUS SYSTEM AND PANCREATIC RECEPTORS WILL BE DETERMINED. ADDITIONALLY, THE PEPTIDES WILL BE SCREENED FOR EITHER AGONIST ACTIVITY OR ANTAGONISM IN ANIMAL BEHAVIOR PARADIGMS AND IN GUINEA PIG PANCREATIC ACINAR CELL SECRETION. THUS POTENTIAL CENTRALLY, BEHAVIORALLY AND PHYSIOLOGICALLY ACTIVE PEPTIDES, SUITABLE FOR THE STUDY OF CHOLECYSTOKININ FUNCTION WILL BE IDENTIFIED. THE PEPTIDES ARE TO BE MADE AVAILABLE FOR RESEARCH IN FOOD-RELATED BEHAVIORS AND PRE-CLINICAL RESEARCH IN AREAS RELATING TO NEUROLOGICAL AND GASTROINTESTINAL DISEASES. METHODS TO PREPARE LARGE AMOUNTS OF THE MOST ACTIVE PEPTIDESARE PROPOSED TO BE DEVELOPED. THESE INCLUDE MODIFICATION OF THE CHEMICAL SYNTHETIC PROCEDURE AND USE OF A PREPARATIVE- SCALE COIL PLANET CENTRIFUGE TO BE CUSTOM BUILT FOR THIS PURPOSE.

Principal Investigator:

Martha knight
DIRECTOR
0

Business Contact:

Martha Knight
Director Of Research
Small Business Information at Submission:

Peptide Technologies, Inc.
4970 Battery Lane #508 Bethesda, MD 20814

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No