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THE SYNTHESES OF 19 CHOLECYSTOKININ-OCTAPEPTIDE ANALOGUES ARE PROPOSED.

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
3297
Program Year/Program:
1985 / SBIR
Agency Tracking Number:
3297
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Peptide Technolgies Corp.
PO BOX 368 MAIN 125 MICHIGAN AVE NE Washington, DC 20017
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Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1985
Title: THE SYNTHESES OF 19 CHOLECYSTOKININ-OCTAPEPTIDE ANALOGUES ARE PROPOSED.
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE SYNTHESES OF 19 CHOLECYSTOKININ-OCTAPEPTIDE ANALOGUES ARE PROPOSED. THE PREPARATION OF THESE PEPTIDES WILL INVOLVE SOLID-PHASE TECHNIQUES AND PURIFICATION OF A NEW INSTRUMENT FOR COUNTER-CURRENT CHROMATOGRAPHY, THE HORIZONTAL FLOW-THROUGH COIL PLANET CENTRIFUGE. THE BINDING OF THESE PEPTIDES TO CHOLECYSTOKININ CENTRAL NERVOUS SYSTEM AND PANCREATIC RECEPTORS WILL BE DETERMINED. ADDITIONALLY, THE PEPTIDES WILL BE SCREENED FOR EITHER AGONIST ACTIVITY OR ANTAGONISM IN ANIMAL BEHAVIOR PARADIGMS AND IN GUINEA PIG PANCREATIC ACINAR CELL SECRETION. THUS POTENTIAL CENTRALLY, BEHAVIORALLY, AND PSYSIOLOGICALLY ACTIVE PEPTIDES, SUITABLE FOR THE STUDY OF CHOLECYSTOKININ FUNCTION, WILL BE IDENTIFIED. THE PEPTIDES ARE TO BE MADE AVAILABLE FOR RESEARCH IN FOOD-RELATED BEHAVIORS AND PRECLINICAL RESEARCH IN AREAS RELATING TO NEUROLOGICAL AND GASTROINTESTINAL DISEASES. METHODS TO PREPARE LARGE AMOUNTS OF THE MOST ACTIVE PEPTIDES WILL BE DEVELOPED. THESE INCLUDE MODIFICATION OF THE CHEMICAL SYNTHETIC PROCEDURE AND USE OF A PREPARATIVE-SCALE COIL PLANET CENTRIFUGE TO BE CUSTOM BUILT FOR THIS PURPOSE.

Principal Investigator:

Martha knight
PRINCIPAL INVESTIGATOR
2022343384

Business Contact:

Small Business Information at Submission:

Peptide Technologies Corp
125 Michigan Ave.,n.e. Washington, DC 20017

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No