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SYNTHESIS OF VISCOSIN, A POTENTIAL THERAPEUTIC FOR CHAGAS' DISEASE

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
4700
Program Year/Program:
1987 / SBIR
Agency Tracking Number:
4700
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Peptide Technolgies Corp.
PO BOX 368 MAIN 125 MICHIGAN AVE NE Washington, DC 20017
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Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1987
Title: SYNTHESIS OF VISCOSIN, A POTENTIAL THERAPEUTIC FOR CHAGAS' DISEASE
Agency: HHS
Contract: N/A
Award Amount: $204,000.00
 

Abstract:

THE ANTIBIOTIC VISCOSIN, A CYCLIC DEPSIPEPTIDE ISOLATED FROMPSEUDOMONAS VISCOSA, SHOWS PROMISING IN VITRO AND IN VIVO (MICE) CYTOTOXICITY AGAINST TRYPANOSOMA CRUZI, THE CAUSATIVEAGENT IN CHAGAS" DISEASE. THE TOTAL SYNTHESIS OF VISCOSIN IS PROPOSED IN ORDER TO CONFIRM ITS CHEMICAL STRUCTURE AND AND TO PROVIDE MATERIAL FOR RESEARCH. METHODS DEVELOPED DURING SYNTHESIS WILL BE USEFUL FOR FUTURE SYNTHESIS OF FRAGMENTS AND ANALOGS NECESSARY TO DETERMINE THE STRUCTURE- ACTIVITY RELATIONSHIPS OF THE COMPOUND. VISCOSIN AND RELATED COMPOUNDS REPRESENT A POTENTIAL CLASS OF CHEMOTHERAPEUTIC AGENTS FOR CHAGAS' DISEASE WHICH AT PRESENTIS AN INCURABLE AND POTENTIALLY FATAL DISEASE AFFECTING MILLIONS OF PEOPLE.

Principal Investigator:

Terrence R Burke Jr
Principal Investigator
2022343384

Business Contact:

Small Business Information at Submission:

Peptide Technologies Corp.
4970 Battery Lane Suite 508 Bethesda, MD 20814

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No