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ENDOTHELIN ANTAGONIST

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
11331
Program Year/Program:
1989 / SBIR
Agency Tracking Number:
11331
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Peptide Technolgies Corp.
PO BOX 368 MAIN 125 MICHIGAN AVE NE Washington, DC 20017
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Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1989
Title: ENDOTHELIN ANTAGONIST
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

ENDOTHELIN IS A POTENT VASOACTIVE PEPTIDE, RECENTLY DISCOVERED AS THE FORMERLY DESCRIBED ENDOTHELIAL CELL-DERIVED CONTRACTING FACTOR INVOLVED IN THE REGULATION OF VASCULAR TONE. ALTHOUGH ENDOTHELIN POSSESSES POTENT VASOCONSTRICTOR ACTIVITY IN VITRO, ITS ACTIONS IN VIVO APPEAR TO BE COMPLEX. IN THE SYSTEMIC AND RENAL VASCULAR BEDS, VASODILATION SEEMS TO BE THE INITIAL EFFECT. IN THE PULMONARY AND MESENTERIC VASCULAR BEDS, ENDOTHELIN PRODUCES VASOCONSTRICTION. ENDOTHELIN STIMULATES THE GROWTH OF SMOOTH MUSCLE CELLS AND MAY PLAY A ROLE IN ATHEROSCLEROSIS. AN ANTAGONIST OF ENDOTHELIN WILL SERVE TO CHARACTERIZE ITS RECEPTOR INTERACTION AND PHYSIOLOGICAL EFFECTS. ANALOGS WILL BE SYNTHESIZED AND TESTED FOR THE INHIBITION OF ENDOTHELIN ACTIONS ON VASCULAR CONDUCTANCE. A POSSIBLE THERAPEUTIC AGENT FOR ATHEROSCLEROSIS AND HYPERTENSION, AS WELL AS ACUTEINJURY AND SHOCK, MAY THUS BE DEVELOPED.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Peptide Technologies Corp
Box 368 Main 125 Michigan Ave Ne Washington, DC 20017

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No